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MedKoo Cat#: 330157 | Name: Clobetasone Butyrate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clobetasone is a corticosteroid used in dermatology, for treating such skin inflammation as seen in eczema, psoriasis and other forms of dermatitis, and ophthalmology. Topical clobetasone butyrate has shown minimal suppression of the Hypothalamic-pituitary-adrenal axis. It is available as clobetasone butyrate under the brand names Eumosone or Eumovate both manufactured by GlaxoSmithKline.

Chemical Structure

Clobetasone Butyrate
Clobetasone Butyrate
CAS#25122-57-0 (butyrate)

Theoretical Analysis

MedKoo Cat#: 330157

Name: Clobetasone Butyrate

CAS#: 25122-57-0 (butyrate)

Chemical Formula: C26H32ClFO5

Exact Mass: 478.1922

Molecular Weight: 478.99

Elemental Analysis: C, 65.20; H, 6.73; Cl, 7.40; F, 3.97; O, 16.70

Price and Availability

Size Price Availability Quantity
50mg USD 250.00 2 Weeks
250mg USD 650.00 2 Weeks
1g USD 1,450.00 2 Weeks
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Related CAS #
54063-32-0 (free base) 25122-57-0 (butyrate)
Synonym
Clobetasone Butyrate; Clobetasone 17-butyrate; SN203; SN-203; SN 203; Cloptison; Emovate; Eumovate; GR 2/1214; Molivate.
IUPAC/Chemical Name
21-Chloro-9-fluoro-17-hydroxy-16beta-methylpregna-1,4-diene-3,11,20-trione 17-butyrate
InChi Key
FBRAWBYQGRLCEK-AVVSTMBFSA-N
InChi Code
InChI=1S/C26H32ClFO5/c1-5-6-22(32)33-26(21(31)14-27)15(2)11-19-18-8-7-16-12-17(29)9-10-23(16,3)25(18,28)20(30)13-24(19,26)4/h9-10,12,15,18-19H,5-8,11,13-14H2,1-4H3/t15-,18-,19-,23-,24-,25-,26-/m0/s1
SMILES Code
C[C@@]1(C2)[C@](C(CCl)=O)(OC(CCC)=O)[C@@H](C)C[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)C2=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 478.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yamamoto Y, Fukami T, Koide T, Onuki Y, Suzuki T, Metori K, Katori N, Hiyama Y, Tomono K. Comparative pharmaceutical evaluation of brand and generic clobetasone butyrate ointments. Int J Pharm. 2014 Mar 10;463(1):62-7. doi: 10.1016/j.ijpharm.2013.12.054. Epub 2014 Jan 7. PubMed PMID: 24406671. 2: Aragona P, Spinella R, Rania L, Postorino E, Sommario MS, Roszkowska AM, Puzzolo D. Safety and efficacy of 0.1% clobetasone butyrate eyedrops in the treatment of dry eye in Sjögren syndrome. Eur J Ophthalmol. 2013 May-Jun;23(3):368-76. doi: 10.5301/ejo.5000229. Epub 2012 Nov 19. PubMed PMID: 23225089. 3: Cohen SN, Lim RP, Paul CJ, Abdullah A. Equal efficacy of topical tacrolimus and clobetasone butyrate in pemphigus foliaceus. Int J Dermatol. 2006 Nov;45(11):1379. PubMed PMID: 17076736. 4: Goustas P, Cork MJ, Higson D. Eumovate (clobetasone butyrate 0.05%) cream: a review of clinical efficacy and safety. J Dermatolog Treat. 2003 Jun;14(2):71-85. Review. PubMed PMID: 12775314. 5: Parneix-Spake A, Goustas P, Green R. Eumovate (clobetasone butyrate) 0.05% cream with its moisturizing emollient base has better healing properties than hydrocortisone 1% cream: a study in nickel-induced contact dermatitis. J Dermatolog Treat. 2001 Dec;12(4):191-7. PubMed PMID: 12241627. 6: Harrison DA, Smith AG. Concomitant sensitivity to sodium metabisulfite and clobetasone butyrate in Trimovate cream. Contact Dermatitis. 2002 May;46(5):310. PubMed PMID: 12084093. 7: Murata T, Tanaka M, Dekio I, Tanikawa A, Nishikawa T. Allergic contact dermatitis due to clobetasone butyrate. Contact Dermatitis. 2000 May;42(5):305. PubMed PMID: 10789866. 8: Wolkerstorfer A, Strobos MA, Glazenburg EJ, Mulder PG, Oranje AP. Fluticasone propionate 0.05% cream once daily versus clobetasone butyrate 0.05% cream twice daily in children with atopic dermatitis. J Am Acad Dermatol. 1998 Aug;39(2 Pt 1):226-31. PubMed PMID: 9704834. 9: Kadom AH, Forrester JV, Williamson TH. Comparison of the anti-inflammatory activity and effect on intraocular pressure of fluoromethalone, clobetasone butyrate and betamethasone phosphate eye drops. Ophthalmic Physiol Opt. 1986;6(3):313-5. PubMed PMID: 3547254. 10: Bonavita E, Bassi R, Mengoni M. [Clobetasone butyrate, a topical steroid in geriatrics]. Clin Ter. 1985 Mar 15;112(5):423-8. Italian. PubMed PMID: 4017467. 11: Boner AL, Richelli C, De Stefano G, Valletta EA, Ferrari S, Mengoni M. Hypothalamic-pituitary-adrenal function in children with atopic dermatitis treated with clobetasone butyrate and its clinical evaluation. Int J Clin Pharmacol Ther Toxicol. 1985 Feb;23(2):118-20. PubMed PMID: 2985514. 12: Boner AL, Richelli C, De Stefano G, Antolini I, Aprili F, Mengoni M. Adrenocortical function during prolonged treatment with clobetasone butyrate in children with chronic atopic dermatitis and elevated IgE levels. Int J Clin Pharmacol Res. 1985;5(2):127-31. PubMed PMID: 4018942. 13: Lassus A. Alclometasone dipropionate cream 0.05% versus clobetasone butyrate cream 0.05%. A controlled clinical comparison in the treatment of atopic dermatitis in children. Int J Dermatol. 1984 Oct;23(8):565-6. PubMed PMID: 6389385. 14: Dooms-Goossens A, Vanhee J, Vanderheyden D, Gevers D, Willems L, Degreef H. Allergic contact dermatitis to topical corticosteroids: clobetasol propionate and clobetasone butyrate. Contact Dermatitis. 1983 Nov;9(6):470-8. PubMed PMID: 6653104. 15: Chalmers RJ, Beck MH, Muston HL. Simultaneous hypersensitivity to clobetasone butyrate and clobetasol propionate. Contact Dermatitis. 1983 Jul;9(4):317-8. PubMed PMID: 6225613. 16: Hehir M, Du Vivier A, Eilon L, Danie MJ, Shenoy EV. Investigation of the pharmacokinetics of clobetasol propionate and clobetasone butyrate after a single application of ointment. Clin Exp Dermatol. 1983 Mar;8(2):143-51. PubMed PMID: 6851236. 17: Debnath SC, Richards AB. Concentration of clobetasone butyrate in aqueous humour. Br J Ophthalmol. 1983 Mar;67(3):203-5. PubMed PMID: 6824626; PubMed Central PMCID: PMC1040009. 18: Haribhakti PB. Comparative Study of Clobetasone Butyrate Cream (eumovate) and Hydrocortisone Cream in Children with Eczema. Indian J Dermatol Venereol Leprol. 1982 Nov-Dec;48(6):344-347. PubMed PMID: 28193917. 19: Eilon LA, Walker SR. Clinical evaluation of clobetasone butyrate eye drops in the treatment of anterior uveitis and its effects on intraocular pressure. Br J Ophthalmol. 1981 Sep;65(9):644-7. PubMed PMID: 7028089; PubMed Central PMCID: PMC1039614. 20: Lloyd-Jones D, Tokarewicz A, Watson PG. Clinical evaluation of clobetasone butyrate eye drops in episcleritis. Br J Ophthalmol. 1981 Sep;65(9):641-3. PubMed PMID: 7028088; PubMed Central PMCID: PMC1039613.