MedKoo Cat#: 413057 | Name: Tridihexethyl iodide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tridihexethyl iodide is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract.

Chemical Structure

Tridihexethyl iodide
Tridihexethyl iodide
CAS#125-99-5 (iodide)

Theoretical Analysis

MedKoo Cat#: 413057

Name: Tridihexethyl iodide

CAS#: 125-99-5 (iodide)

Chemical Formula: C21H36INO

Exact Mass: 445.1842

Molecular Weight: 445.43

Elemental Analysis: C, 56.63; H, 8.15; I, 28.49; N, 3.14; O, 3.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
Synonym
Tridihexethyl iodide; Pathilon; Claviton; Propethonum
IUPAC/Chemical Name
(3-Cyclohexyl-3-hydroxy-3-phenylpropyl)triethylammonium iodide
InChi Key
VFEDLMLHAGASHB-UHFFFAOYSA-M
InChi Code
InChI=1S/C21H36NO.HI/c1-4-22(5-2,6-3)18-17-21(23,19-13-9-7-10-14-19)20-15-11-8-12-16-20;/h7,9-10,13-14,20,23H,4-6,8,11-12,15-18H2,1-3H3;1H/q+1;/p-1
SMILES Code
CC[N+](CC)(CCC(O)(C1CCCCC1)C2=CC=CC=C2)CC.[I-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 445.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: OSTERBERG AC, GRAY WD. The anticholinergic actions of tridihexethyl iodide. Arch Int Pharmacodyn Ther. 1962 Jun 1;137:250-66. PMID: 14482588. 2: Leigh RJ, Burnstine TH, Ruff RL, Kasmer RJ. Effect of anticholinergic agents upon acquired nystagmus: a double-blind study of trihexyphenidyl and tridihexethyl chloride. Neurology. 1991 Nov;41(11):1737-41. doi: 10.1212/wnl.41.11.1737. PMID: 1944902. 3: SLATER S, NUMEROFF M. Effect of meprobamate-tridihexethyl iodide on the uptake of radioactive iodine and on the serum protein-bound iodine. N Engl J Med. 1958 Nov 13;259(20):974-5. doi: 10.1056/NEJM195811132592007. PMID: 13600606. 4: GARCIAHERRERA E, GARCIAHERRERA A. TRATAMIENTO DEL ESPASMO GASTROINTESTINAL DEL NI NO CON UNA SOLUCI'ON DE CLORURO DE TRIDIHEXETILO [TREATMENT OF GASTROINTESTINAL SPASM IN THE CHILD WITH A SOLUTION OF TRIDIHEXETHYL CHLORIDE]. Medicina (Mex). 1963 Oct 10;43:475-80. Spanish. PMID: 14107303. 5: Lippold BC, Lettenbauer WA. Resorption homologer Alkylsulfonate des Tridihexethyls [The absorption of homologous alkyl sulphonates of tridihexethyl (author's transl)]. Pharmazie. 1980;35(10):612-20. German. PMID: 6256779. 6: Kirchhoefer RD. Semiautomated determination of tridihexethyl chloride in meprobamate tablets. J Assoc Off Anal Chem. 1984 Jul-Aug;67(4):677-8. PMID: 6469893. 7: Lippold BC, Lettenbauer WA. Membrandiffusion homologer organischer Salze des Tridihexäthyls [Membrane diffusion of homologous organic salts of tridihexethyl]. Pharmazie. 1978 Apr;33(4):221-5. German. PMID: 674319. 8: Applegate RA, Soriano T, Perry C, Elam J. Transient visual anomalies associated with drug treatment for spastic colon. J Am Optom Assoc. 1986 Aug;57(8):604-6. PMID: 3489028. 9: Sofia RD, Diamantis W, Harrison JE, Melton J. Evaluation of antiulcer activity of delta9-tetrahydrocannabinol in the Shay rat test. Pharmacology. 1978;17(3):173-7. doi: 10.1159/000136851. PMID: 704660. 10: PHILLIPS FJ. Peptic ulcer: treatment with a combination of meprobamate and tridihexethyl chloride. Clin Med (Northfield). 1963 Jul;70:1303-6. PMID: 15445911.