JNJ-pan-AR | CAS#unknown | pan-AR antagonist

MedKoo Cat#: 463852 | Name: JNJ-pan-AR

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JNJ-pan-AR, a meylated analogue of JNJ-63576253, is a novel pan-AR antagonist with potent activity against wild-type and clinically relevant AR mutations including F877L. JNJ63576253, also known as TRC253, is a potent and orally active androgen receptor antagonist. TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus.

Chemical Structure

JNJ-pan-AR

CAS#1332390-06-3 (free base)

Theoretical Analysis

MedKoo Cat#: 463852

Name: JNJ-pan-AR

CAS#: 1332390-06-3 (free base)

Chemical Formula: C25H24F3N5O2S

Exact Mass: 515.1603

Molecular Weight: 515.56

Elemental Analysis: C, 58.24; H, 4.69; F, 11.06; N, 13.58; O, 6.21; S, 6.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

1332390-06-3 (free base) 2720510-67-6 (HCl)

Synonym

JNJ-pan-AR; JNJpan-AR; JNJ pan-AR; JNJ-pan AR; JNJ-panAR; JNJpanAR; JNJ pan AR; Methylated-JNJ-63576253; Methylated-JNJ63576253; Methylated-JNJ 63576253;

IUPAC/Chemical Name

5-(5-(4-((1-methylpiperidin-4-yl)oxy)phenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile

InChi Key

IZKSMIBPGSWAMO-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H24F3N5O2S/c1-31-11-7-19(8-12-31)35-18-5-3-16(4-6-18)33-23(36)32(22(34)24(33)9-2-10-24)17-13-20(25(26,27)28)21(14-29)30-15-17/h3-6,13,15,19H,2,7-12H2,1H3

SMILES Code

N#CC1=NC=C(N(C2=O)C(N(C3=CC=C(OC4CCN(C)CC4)C=C3)C52CCC5)=S)C=C1C(F)(F)F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 515.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhang Z, Connolly PJ, Lim HK, Pande V, Meerpoel L, Teleha C, Branch JR, Ondrus J, Hickson I, Bush T, Luistro L, Packman K, Bischoff JR, Ibrahim S, Parrett C, Chong Y, Gottardis MM, Bignan G. Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC). J Med Chem. 2021 Jan 20. doi: 10.1021/acs.jmedchem.0c01563. Epub ahead of print. PMID: 33470111. 2: Hertzog JR, Zhang Z, Bignan G, Connolly PJ, Heindl JE, Janetopoulos CJ, Rupnow BA, McDevitt TM. AKR1C3 mediates pan-AR antagonist resistance in castration-resistant prostate cancer. Prostate. 2020 Oct;80(14):1223-1232. doi: 10.1002/pros.24049. Epub 2020 Jul 31. PMID: 33258507.