CJ-15161 hydrochloride | CAS# 204970-99-0 (HCl)| opioid κ-receptor agonist

MedKoo Cat#: 412983 | Name: CJ-15161 hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CJ-15161 hydrochloride is the salt form of CJ-15161 (free base), an opioid κ-receptor agonist, is undergoing development with Pfizer as an analgesic agent.

Chemical Structure

CJ-15161 hydrochloride

CAS#204970-99-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 412983

Name: CJ-15161 hydrochloride

CAS#: 204970-99-0 (HCl)

Chemical Formula: C23H32ClN3O2

Exact Mass:

Molecular Weight: 417.98

Elemental Analysis: C, 66.09; H, 7.72; Cl, 8.48; N, 10.05; O, 7.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

204970-99-0 (HCl) 204970-97-8 (free base)

Synonym

CJ-15161 hydrochloride; CJ15161 hydrochloride; CJ 15161 hydrochloride

IUPAC/Chemical Name

Benzamide, 4-(((1S)-2-((3S)-3-hydroxy-1-pyrrolidinyl)-1-phenylethyl)methylamino)-N-propyl-, hydrochloride (1:1)

InChi Key

UIDQSFVIAHCPLD-UMIAIAFLSA-N

InChi Code

InChI=1S/C23H31N3O2.ClH/c1-3-14-24-23(28)19-9-11-20(12-10-19)25(2)22(18-7-5-4-6-8-18)17-26-15-13-21(27)16-26;/h4-12,21-22,27H,3,13-17H2,1-2H3,(H,24,28);1H/t21-,22+;/m0./s1

SMILES Code

O=C(NCCC)C1=CC=C(N([C@@H](C2=CC=CC=C2)CN3C[C@@H](O)CC3)C)C=C1.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 417.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ghosh A, Sieser JE, Caron S, Couturier M, Dupont-Gaudet K, Girardin M. Cu- catalyzed N-arylation of oxazolidinones: an efficient synthesis of the kappa- opioid receptor Agonist CJ-15161. J Org Chem. 2006 Feb 3;71(3):1258-61. doi: 10.1021/jo052060z. PMID: 16438550. 2: Ghosh A, Sieser JE, Caron S, Watson TJ. Synthesis of the kappa-agonist CJ-15,161 via a palladium-catalyzed cross-coupling reaction. Chem Commun (Camb). 2002 Aug 7;(15):1644-5. doi: 10.1039/b204844b. PMID: 12170823.