IUPAC/Chemical Name
Yadanzioside A
InChi Key
QDQJWSSPAMZRIA-KEMICICVSA-N
InChi Code
InChI=1S/C32H44O16/c1-11(2)6-17(34)48-23-25-31-10-44-32(25,29(42)43-5)26(40)22(39)24(31)30(4)8-14(18(35)12(3)13(30)7-16(31)47-27(23)41)45-28-21(38)20(37)19(36)15(9-33)46-28/h8,11-13,15-16,19-26,28,33,36-40H,6-7,9-10H2,1-5H3/t12-,13+,15-,16-,19-,20+,21-,22-,23-,24-,25-,26+,28-,30+,31-,32+/m1/s1
SMILES Code
C1(=C[C@@]2([C@H]3[C@H]([C@@H]([C@@]4([C@H]5[C@@]3([C@@H](C[C@H]2[C@@H](C)C1=O)OC([C@@H]5OC(=O)CC(C)C)=O)CO4)C(=O)OC)O)O)C)O[C@H]1[C@@H]([C@@H](O)[C@@H]([C@H](O1)CO)O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
684.69
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Liu JQ, Wang CF, Li XY, Chen JC, Li Y, Qiu MH. One new pregnane glycoside from the seeds of cultivated Brucea javanica. Arch Pharm Res. 2011 Aug;34(8):1297-300. doi: 10.1007/s12272-011-0809-5. Epub 2011 Sep 11. PubMed PMID: 21910051.
2: Zhao M, Lau ST, Leung PS, Che CT, Lin ZX. Seven quassinoids from Fructus Bruceae with cytotoxic effects on pancreatic adenocarcinoma cell lines. Phytother Res. 2011 Dec;25(12):1796-800. doi: 10.1002/ptr.3477. Epub 2011 Apr 8. PubMed PMID: 21480411.
3: Yan XH, Chen J, Di YT, Fang X, Dong JH, Sang P, Wang YH, He HP, Zhang ZK, Hao XJ. Anti-tobacco mosaic virus (TMV) Quassinoids from Brucea javanica (L.) Merr. J Agric Food Chem. 2010 Feb 10;58(3):1572-7. doi: 10.1021/jf903434h. PubMed PMID: 20050684.
4: Kim IH, Takashima S, Hitotsuyanagi Y, Hasuda T, Takeya K. New quassinoids, javanicolides C and D and javanicosides B--F, from seeds of Brucea javanica. J Nat Prod. 2004 May;67(5):863-8. PubMed PMID: 15165151.
5: Okuyama E, Gao LH, Yamazaki M. [Studies on pharmacologically active principles from Indonesian crude drugs. III. Toxic components from Brucea javanica (L.) Merr]. Yakugaku Zasshi. 1990 Nov;110(11):834-8. Japanese. PubMed PMID: 2082013.
6: Okano M, Fukamiya N, Toyota T, Tagahara K, Lee KH. Antitumor agents, 104. Isolation of yadanziosides M and P from Brucea antidysenterica and identification of bruceantinoside B as a mixture of yadanzioside P and bruceantinoside C. J Nat Prod. 1989 Mar-Apr;52(2):398-401. PubMed PMID: 2746262.
7: Sakaki T, Yoshimura S, Tsuyuki T, Takahashi T, Honda T. Yadanzioside P, a new antileukemic quassinoid glycoside from Brucea javanica (L.) Merr with the 3-O-(beta-D-glucopyranosyl)bruceantin structure. Chem Pharm Bull (Tokyo). 1986 Oct;34(10):4447-50. PubMed PMID: 3829175.
