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MedKoo Cat#: 575661 | Name: Fradafiban

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fradafiban is a nonpeptide platelet glycoprotein IIb/IIIa antagonist that has been shown to inhibit platelet aggregation.

Chemical Structure

Fradafiban
Fradafiban
CAS#148396-36-5

Theoretical Analysis

MedKoo Cat#: 575661

Name: Fradafiban

CAS#: 148396-36-5

Chemical Formula: C20H21N3O4

Exact Mass: 367.1532

Molecular Weight: 367.40

Elemental Analysis: C, 65.38; H, 5.76; N, 11.44; O, 17.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Fradafiban
IUPAC/Chemical Name
(3S,5S)-5-(((4'-Amidino-4-biphenylyl)oxy)methyl)-2-oxo-3-pyrrolidineacetic acid
InChi Key
IKZACQMAVUIGPY-HOTGVXAUSA-N
InChi Code
InChI=1S/C20H21N3O4/c21-19(22)14-3-1-12(2-4-14)13-5-7-17(8-6-13)27-11-16-9-15(10-18(24)25)20(26)23-16/h1-8,15-16H,9-11H2,(H3,21,22)(H,23,26)(H,24,25)/t15-,16-/m0/s1
SMILES Code
NC(=N)c1ccc(cc1)c2ccc(OC[C@@H]3C[C@@H](CC(=O)O)C(=O)N3)cc2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 367.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Müller TH, Weisenberger H, Brickl R, Narjes H, Himmelsbach F, Krause J. Profound and sustained inhibition of platelet aggregation by Fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men. Circulation. 1997 Aug 19;96(4):1130-8. doi: 10.1161/01.cir.96.4.1130. PMID: 9286940. 2. Byrne A, Moran N, Maher M, Walsh N, Crean P, Fitzgerald DJ. Continued thromboxane A2 formation despite administration of a platelet glycoprotein IIb/IIIa antagonist in patients undergoing coronary angioplasty. Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):3224-9. doi: 10.1161/01.atv.17.11.3224. PMID: 9409315.