Synonym
Flavonoid 11; Flavonoid-11; 3'-Hydroxy-3,4'-dimethoxyflavone;
IUPAC/Chemical Name
2-(3-hydroxy-4-methoxyphenyl)-3-methoxy-4H-chromen-4-one
InChi Key
AZHLWAUYEUEQAA-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H14O5/c1-20-14-8-7-10(9-12(14)18)16-17(21-2)15(19)11-5-3-4-6-13(11)22-16/h3-9,18H,1-2H3
SMILES Code
OC1=CC(C(OC2=C(C3=O)C=CC=C2)=C3OC)=CC=C1OC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
298.29
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Estévez-Sarmiento F, Hernández E, Brouard I, León F, García C, Quintana J, Estévez F. 3'-Hydroxy-3,4'-dimethoxyflavone-induced cell death in human leukaemia cells is dependent on caspases and reactive oxygen species and attenuated by the inhibition of JNK/SAPK. Chem Biol Interact. 2018 May 25;288:1-11. doi: 10.1016/j.cbi.2018.04.006. Epub 2018 Apr 6. PMID: 29630880.
2: Estévez-Sarmiento F, Said M, Brouard I, León F, García C, Quintana J, Estévez F. 3'-Hydroxy-3,4'-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells. Bioorg Med Chem. 2017 Nov 1;25(21):6060-6070. doi: 10.1016/j.bmc.2017.09.043. Epub 2017 Oct 3. PMID: 29032930.
3: Zhang J, Pang DR, Huang Z, Huo HX, Li YT, Zheng J, Zhang Q, Zhao YF, Tu PF, Li J. [Flavonoids from whole plants of Lagopsis supina]. Zhongguo Zhong Yao Za Zhi. 2015 Aug;40(16):3224-8. Chinese. PMID: 26790297.
4: Bae IH, Lee WS, Yun DH, Han YH, Lee JS. 3-Hydroxy-3',4'-dimethoxyflavone suppresses Bcl-w-induced invasive potentials and stemness in glioblastoma multiforme. Biochem Biophys Res Commun. 2014 Jul 18;450(1):704-10. doi: 10.1016/j.bbrc.2014.06.038. Epub 2014 Jun 16. PMID: 24946210.
5: Hayashi T, Yagi C, Ogaki S, Kawai S, Ono T. Fluorometric determination of urinary phosphate with 3-hydroxy-3',4'-dimethoxyflavone-magnesium system. Chem Pharm Bull (Tokyo). 1973 Oct;21(10):2141-5. doi: 10.1248/cpb.21.2141. PMID: 4775965.
