Synonym
Lon 954; Lon-954; Lon954;
IUPAC/Chemical Name
N-carbamoyl-2-(2,6-dichlorophenyl)acetimidamide hydrochloride
InChi Key
AIROWKHOMTWHBV-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(12)14-9(13)15;/h1-3H,4H2,(H4,12,13,14,15);1H
SMILES Code
N=C(NC(N)=O)CC1=C(Cl)C=CC=C1Cl.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
282.54
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Gothóni P. Harmine-, LON-954- and 5-hydroxytryptophan-induced tremors in rats withdrawn from ethanol. Acta Pharmacol Toxicol (Copenh). 1985 Jul;57(1):40-6. PubMed PMID: 3876687.
2: Mohanakumar KP, Ganguly DK. Tremorogenesis by LON-954 [N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride]: evidence for the involvement of 5-hydroxytryptamine. Brain Res Bull. 1989 Feb;22(2):191-5. PubMed PMID: 2706533.
3: Vedasiromoni JR, Ganguly DK. N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride (LON-954), a tremorogen, on rat diaphragm. Jpn J Pharmacol. 1984 Mar;34(3):353-5. PubMed PMID: 6727073.
4: Das M, Chauhan SP, Ganguly DK. Alpha 2-antagonistic effect of N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride (LON-954). Eur J Pharmacol. 1988 Apr 27;149(1-2):55-60. PubMed PMID: 2899516.
5: Mitra C, Ganguly DK, Guha SR. Monoamine oxidase inhibition by the tremorogenic drug--LON 954. J Pharm Pharmacol. 1984 Jun;36(6):408-10. PubMed PMID: 6146677.
6: Coward DM, Doggett NS. Potentiation of LON 954 tremor by typical and atypical neuroleptics--an indication of striatal dopamine antagonism. Psychopharmacology (Berl). 1980 Feb;67(2):177-80. PubMed PMID: 6102779.
7: Ganguly DK, Ross HG, Cleveland S. Electrophysiological studies with LON-954, a tremorogen, in the cat spinal cord. Jpn J Pharmacol. 1984 Oct;36(2):249-52. PubMed PMID: 6513203.
8: Farkas S, Berzsenyi P, Kárpáti E, Kocsis P, Tarnawa I. Simple pharmacological test battery to assess efficacy and side effect profile of centrally acting muscle relaxant drugs. J Pharmacol Toxicol Methods. 2005 Sep-Oct;52(2):264-73. Epub 2005 Jan 12. PubMed PMID: 16125625.
