Synonym
Fludrocortisone hemisuccinate; Fluorinef hemisuccinate; 9α-Fluorohydrocortisone 21-hemisuccinate;
IUPAC/Chemical Name
Pregn-4-ene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-, 21-(hydrogen succinate)
InChi Key
RRDDXLOWDKTRPZ-WRCNZEDTSA-N
InChi Code
InChI=1S/C25H33FO8/c1-22-9-7-15(27)11-14(22)3-4-17-16-8-10-24(33,23(16,2)12-18(28)25(17,22)26)19(29)13-34-21(32)6-5-20(30)31/h11,16-18,28,33H,3-10,12-13H2,1-2H3,(H,30,31)/t16-,17-,18-,22-,23-,24-,25-/m0/s1
SMILES Code
C[C@]12C[C@H](O)[C@@]3(F)[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@]2(O)C(=O)COC(=O)CCC(=O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
480.53
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Fleischer J, Wingenfeld K, Kuehl LK, Hinkelmann K, Roepke S, Otte C. Does fludrocortisone influence autobiographical memory retrieval? A study in patients with major depression, patients with borderline personality disorder and healthy controls. Stress. 2015 Nov;18(6):718-22. doi: 10.3109/10253890.2015.1087504. Epub 2015 Oct 12. PubMed PMID: 26457343.
2: Koutinas CK, Soubasis NC, Djajadiningrat-Laanen SC, Kolia E, Theodorou K. Urinary Aldosterone/Creatinine Ratio After Fludrocortisone Suppression Consistent with PHA in a Cat. J Am Anim Hosp Assoc. 2015 Sep-Oct;51(5):338-41. doi: 10.5326/JAAHA-MS-6201. PubMed PMID: 26355586.
3: Johnson RF, Beltz TG, Johnson AK, Thunhorst RL. Effects of fludrocortisone on water and sodium intake of C57BL/6 mice. Am J Physiol Regul Integr Comp Physiol. 2015 Aug 1;309(3):R247-54. doi: 10.1152/ajpregu.00033.2015. Epub 2015 May 27. PubMed PMID: 26017491; PubMed Central PMCID: PMC4525329.
4: Schultebraucks K, Wingenfeld K, Otte C, Quinkler M. The Role of Fludrocortisone in Cognition and Mood in Patients with Primary Adrenal Insufficiency (Addison's Disease). Neuroendocrinology. 2015 Jul 24. [Epub ahead of print] PubMed PMID: 26227663.
5: Banda J, Lakshmanan R, Vvs SP, Gudla SP, Prudhivi R. A highly sensitive method for the quantification of fludrocortisone in human plasma using ultra-high-performance liquid chromatography tandem mass spectrometry and its pharmacokinetic application. Biomed Chromatogr. 2015 Aug;29(8):1213-9. doi: 10.1002/bmc.3410. Epub 2015 Jan 22. PubMed PMID: 25611194.
