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MedKoo Cat#: 329891 | Name: Fludrocortisone Acetate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fludrocortisone Acetate the acetate form of the synthetic corticosteroid fludrocortisone, which is a mineralocorticoid receptor agonist. Fludrocortisone has been used in the treatment of cerebral salt wasting syndrome.

Chemical Structure

Fludrocortisone Acetate
Fludrocortisone Acetate
CAS#514-36-3 (acetate)

Theoretical Analysis

MedKoo Cat#: 329891

Name: Fludrocortisone Acetate

CAS#: 514-36-3 (acetate)

Chemical Formula: C23H31FO6

Exact Mass: 422.2105

Molecular Weight: 422.49

Elemental Analysis: C, 65.39; H, 7.40; F, 4.50; O, 22.72

Price and Availability

Size Price Availability Quantity
1g USD 350.00 2 Weeks
2g USD 550.00 2 Weeks
5g USD 1,050.00 2 Weeks
10g USD 1,650.00 2 Weeks
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Related CAS #
127-31-1 (free) 514-36-3 (acetate) 339-01-5 (hemisuccinate)
Synonym
Fludrocortisone Acetate; 9α-fluoro Hydrocortisone Acetate; 9-Fluorocortisol acetate; 9-Fluorohydrocortisone acetate; NSC 15186; NSC15186; NSC-15186; U 4845; U-4845; U4845;
IUPAC/Chemical Name
2-((8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
InChi Key
SYWHXTATXSMDSB-GSLJADNHSA-N
InChi Code
InChI=1S/C23H31FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h10,16-18,27,29H,4-9,11-12H2,1-3H3/t16-,17-,18-,20-,21-,22-,23-/m0/s1
SMILES Code
F[C@]12[C@@]([C@@](CC[C@]3(O)C(COC(C)=O)=O)([H])[C@]3(C)C[C@@H]2O)([H])CCC4=CC(CC[C@@]41C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 422.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhao Y, Zhang K, Fent K. Corticosteroid Fludrocortisone Acetate Targets Multiple End Points in Zebrafish (Danio rerio) at Low Concentrations. Environ Sci Technol. 2016 Sep 20;50(18):10245-54. doi: 10.1021/acs.est.6b03436. Epub 2016 Sep 12. PubMed PMID: 27618422. 2: Fortunato JE, Wagoner AL, Harbinson RL, D'Agostino RB Jr, Shaltout HA, Diz DI. Effect of fludrocortisone acetate on chronic unexplained nausea and abdominal pain in children with orthostatic intolerance. J Pediatr Gastroenterol Nutr. 2014 Jul;59(1):39-43. doi: 10.1097/MPG.0000000000000305. PubMed PMID: 25222805. 3: Whyte IM, Prior FH, Emslie IK, Davies PE, Cosgrove J. Posterior subcapsular cataract in association with fludrocortisone acetate therapy. Clin Exp Ophthalmol. 2014 Nov;42(8):799-800. doi: 10.1111/ceo.12326. Epub 2014 May 5. PubMed PMID: 24641708. 4: Nagelreiter C, Raffeiner S, Geyerhofer C, Klang V, Valenta C. Influence of drug content, type of semi-solid vehicle and rheological properties on the skin penetration of the model drug fludrocortisone acetate. Int J Pharm. 2013 May 1;448(1):305-12. doi: 10.1016/j.ijpharm.2013.03.042. Epub 2013 Mar 28. PubMed PMID: 23541986. 5: Kato J, Mori T, Kamo M, Tanikawa A, Iketani O, Okamoto S. Hypersensitivity to fludrocortisone acetate in a recipient of bone marrow transplantation. Allergol Int. 2011 Dec;60(4):557-8. doi: 10.2332/allergolint.10-LE-0301. Epub 2011 Jun 25. PubMed PMID: 21681020. 6: Djajadiningrat-Laanen SC, Galac S, Cammelbeeck SE, van Laar KJ, Boer P, Kooistra HS. Urinary aldosterone to creatinine ratio in cats before and after suppression with salt or fludrocortisone acetate. J Vet Intern Med. 2008 Nov-Dec;22(6):1283-8. doi: 10.1111/j.1939-1676.2008.0166.x. Epub 2008 Sep 4. PubMed PMID: 18775055. 7: Kim DM, Chung JH, Yoon SH, Kim HL. Effect of fludrocortisone acetate on reducing serum potassium levels in patients with end-stage renal disease undergoing haemodialysis. Nephrol Dial Transplant. 2007 Nov;22(11):3273-6. Epub 2007 Jul 5. PubMed PMID: 17616536. 8: Gibaud S, Jabir Al Awwadi N, Ducki C, Astier A. Poly(epsilon-caprolactone) and Eudragit microparticles containing fludrocortisone acetate. Int J Pharm. 2004 Jan 28;269(2):491-508. PubMed PMID: 14706260. 9: Cisternino S, Schlatter J, Saulnier JL. Stability of fludrocortisone acetate solutions prepared from tablets and powder. Eur J Pharm Biopharm. 2003 Mar;55(2):209-13. PubMed PMID: 12637099. 10: Rowe PC, Calkins H, DeBusk K, McKenzie R, Anand R, Sharma G, Cuccherini BA, Soto N, Hohman P, Snader S, Lucas KE, Wolff M, Straus SE. Fludrocortisone acetate to treat neurally mediated hypotension in chronic fatigue syndrome: a randomized controlled trial. JAMA. 2001 Jan 3;285(1):52-9. PubMed PMID: 11150109. 11: Scott WA, Pongiglione G, Bromberg BI, Schaffer MS, Deal BJ, Fish FA, Dick M. Randomized comparison of atenolol and fludrocortisone acetate in the treatment of pediatric neurally mediated syncope. Am J Cardiol. 1995 Aug 15;76(5):400-2. PubMed PMID: 7639169. 12: Igarashi Y. [Synthetic mineralocorticoid, clinical application of fludrocortisone acetate (Florinef)]. Nihon Rinsho. 1994 Mar;52(3):779-86. Review. Japanese. PubMed PMID: 8164382. 13: Underwood KA, McCutcheon NB, Dudek BC. The effects of fludrocortisone acetate and deoxycorticosterone acetate on salt appetite in mice. Physiol Behav. 1993 Oct;54(4):671-5. PubMed PMID: 8248344. 14: Hasan D, Lindsay KW, Wijdicks EF, Murray GD, Brouwers PJ, Bakker WH, van Gijn J, Vermeulen M. Effect of fludrocortisone acetate in patients with subarachnoid hemorrhage. Stroke. 1989 Sep;20(9):1156-61. PubMed PMID: 2672426. 15: Wijdicks EF, Vermeulen M, van Brummelen P, van Gijn J. The effect of fludrocortisone acetate on plasma volume and natriuresis in patients with aneurysmal subarachnoid hemorrhage. Clin Neurol Neurosurg. 1988;90(3):209-14. PubMed PMID: 3197346. 16: Ishikawa S, Saito T, Kaneko K, Okada K, Kuzuya T. [Fludrocortisone acetate-responsive hyponatremia observed in old patients after head injury]. Nihon Naika Gakkai Zasshi. 1987 Jun;76(6):867-73. Japanese. PubMed PMID: 3655499. 17: Ishikawa SE, Saito T, Kaneko K, Okada K, Kuzuya T. Hyponatremia responsive to fludrocortisone acetate in elderly patients after head injury. Ann Intern Med. 1987 Feb;106(2):187-91. PubMed PMID: 3800181. 18: Tokuhiro E, Suwa S, Maesaka H. [Clinical use of fludrocortisone acetate in congenital adrenal hyperplasia. Effect on plasma renin activity and aldosterone (author's transl)]. Horumon To Rinsho. 1980;28(3):345-51. Japanese. PubMed PMID: 6994941. 19: Ast TM, Abdou HM. Analysis of fludrocortisone acetate and its solid dosage forms by high-performance liquid chromatography. J Pharm Sci. 1979 Apr;68(4):421-3. PubMed PMID: 438959. 20: Abdou HM, Ast TM, Cioffi FJ. Semiautomated system for high-pressure liquid chromatographic determination of dissolution rate of fludrocortisone acetate tablets. J Pharm Sci. 1978 Oct;67(10):1397-9. PubMed PMID: 702288.

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