MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 412804 | Name: BRL 15572 free base
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BRL 15572 free base is specific for h5-HT(1D) receptors.

Chemical Structure

BRL 15572 free base
BRL 15572 free base
CAS#734517-40-9 (free base)

Theoretical Analysis

MedKoo Cat#: 412804

Name: BRL 15572 free base

CAS#: 734517-40-9 (free base)

Chemical Formula: C25H27ClN2O

Exact Mass: 406.1812

Molecular Weight: 406.95

Elemental Analysis: C, 73.79; H, 6.69; Cl, 8.71; N, 6.88; O, 3.93

Price and Availability

Size Price Availability Quantity
100mg USD 450.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
193611-72-2 (HCl) 734517-40-9 (free base)
Synonym
BRL 15572; BRL15572; BRL-15572; BRL 15572 free base
IUPAC/Chemical Name
3-(4-(3-chlorophenyl)piperazin-1-yl)-1,1-diphenylpropan-2-ol
InChi Key
QJHCTHPYUOXOGM-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H27ClN2O/c26-22-12-7-13-23(18-22)28-16-14-27(15-17-28)19-24(29)25(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-13,18,24-25,29H,14-17,19H2
SMILES Code
OC(CN1CCN(C2=CC=CC(Cl)=C2)CC1)C(C3=CC=CC=C3)C4=CC=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 406.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Schlicker E, Fink K, Molderings GJ, Price GW, Duckworth M, Gaster L, Middlemiss DN, Zentner J, Likungu J, Göthert M. Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):321-7. doi: 10.1007/pl00005057. PMID: 9303568. 2: Price GW, Burton MJ, Collin LJ, Duckworth M, Gaster L, Göthert M, Jones BJ, Roberts C, Watson JM, Middlemiss DN. SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. doi: 10.1007/pl00005056. PMID: 9303567. 3: Quiñonez-Bastidas GN, Pineda-Farias JB, Flores-Murrieta FJ, Rodríguez- Silverio J, Reyes-García JG, Godínez-Chaparro B, Granados-Soto V, Rocha-González HI. Antinociceptive effect of (-)-epicatechin in inflammatory and neuropathic pain in rats. Behav Pharmacol. 2018 Apr;29(2 and 3-Spec Issue):270-279. doi: 10.1097/FBP.0000000000000320. PMID: 28590304. 4: Godínez-Chaparro B, López-Santillán FJ, Argüelles CF, Villalón CM, Granados- Soto V. Role of 5-HT₁B/₁D receptors in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia produced by antimigraine drugs in rats. Life Sci. 2013 Jun 13;92(22):1046-54. doi: 10.1016/j.lfs.2013.03.023. Epub 2013 Apr 9. PMID: 23583574. 5: Guo L, Zhao L, Ming P, Hong L, Liu A, Li R. Sumatriptan inhibits the electrophysiological activity of ASICs in rat trigeminal ganglion neurons. Eur J Pharmacol. 2018 Dec 15;841:98-103. doi: 10.1016/j.ejphar.2018.10.013. Epub 2018 Oct 16. PMID: 30336137. 6: Mata-Bermudez A, Izquierdo T, de Los Monteros-Zuñiga E, Coen A, Godínez- Chaparro B. Antiallodynic effect induced by [6]-gingerol in neuropathic rats is mediated by activation of the serotoninergic system and the nitric oxide-cyclic guanosine monophosphate-adenosine triphosphate-sensitive K+ channel pathway. Phytother Res. 2018 Dec;32(12):2520-2530. doi: 10.1002/ptr.6191. Epub 2018 Sep 24. PMID: 30251306. 7: Hopwood SE, Stamford JA. Multiple 5-HT(1) autoreceptor subtypes govern serotonin release in dorsal and median raphé nuclei. Neuropharmacology. 2001 Mar;40(4):508-19. doi: 10.1016/s0028-3908(00)00192-1. PMID: 11249960. 8: Diniz DA, Petrocchi JA, Navarro LC, Souza TC, Castor MG, Perez AC, Duarte ID, Romero TR. Serotonin induces peripheral mechanical antihyperalgesic effects in mice. Eur J Pharmacol. 2015 Nov 15;767:94-7. doi: 10.1016/j.ejphar.2015.10.012. Epub 2015 Oct 13. PMID: 26460149. 9: Verheggen R, Hundeshagen AG, Brown AM, Schindler M, Kaumann AJ. 5-HT1B receptor-mediated contractions in human temporal artery: evidence from selective antagonists and 5-HT receptor mRNA expression. Br J Pharmacol. 1998 Aug;124(7):1345-54. doi: 10.1038/sj.bjp.0701929. PMID: 9723944; PMCID: PMC1565520. 10: Vidal-Cantú GC, Jiménez-Hernández M, Rocha-González HI, Villalón CM, Granados-Soto V, Muñoz-Islas E. Role of 5-HT5A and 5-HT1B/1D receptors in the antinociception produced by ergotamine and valerenic acid in the rat formalin test. Eur J Pharmacol. 2016 Jun 15;781:109-16. doi: 10.1016/j.ejphar.2016.04.009. Epub 2016 Apr 8. PMID: 27068146.