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MedKoo Cat#: 412762 | Name: CGS 21595

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CGS 21595 inhibits the formation of 5-hydroxyeicosatetraenoic acid and leukotriene B4; rapidly metabolized to CGS 19213.

Chemical Structure

CGS 21595
CGS 21595
CAS#121412-39-3

Theoretical Analysis

MedKoo Cat#: 412762

Name: CGS 21595

CAS#: 121412-39-3

Chemical Formula: C21H25NO4

Exact Mass: 355.1784

Molecular Weight: 355.43

Elemental Analysis: C, 70.96; H, 7.09; N, 3.94; O, 18.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CGS 21595; CGS21595; CGS-21595
IUPAC/Chemical Name
1,2-Naphthalenediol, 4-(cyclohexylmethylamino)-, diacetate (ester)
InChi Key
XJSRASVZCZCIRO-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H25NO4/c1-14(23)25-20-12-19(22-13-16-8-4-3-5-9-16)17-10-6-7-11-18(17)21(20)26-15(2)24/h6-7,10-12,16,22H,3-5,8-9,13H2,1-2H3
SMILES Code
CC(OC1=CC(NCC2CCCCC2)=C3C=CC=CC3=C1OC(C)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 355.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gunson DE, Sahota PS, Iverson WO, Chau RY, McCormick GM, Traina VM. Toxic peripheral neuropathy with demyelination in Sprague-Dawley rats given CGS 21595 --a 5-lipoxygenase inhibitor. Vet Pathol. 1992 Mar;29(2):145-51. doi: 10.1177/030098589202900207. PMID: 1632058. 2: Classen W, Gunson DE, Iverson WO, Traina VM, Vonau MH, Krinke GJ. Functional and morphological characterization of neuropathy induced with 5-lipoxygenase inhibitor CGS 21595. Exp Toxicol Pathol. 1994 Jul;46(2):119-25. doi: 10.1016/S0940-2993(11)80038-2. PMID: 7987069.