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MedKoo Cat#: 412778 | Name: CGS-7181

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CGS-7181 is a biochemical

Chemical Structure

CGS-7181
CGS-7181
CAS#200345-93-3

Theoretical Analysis

MedKoo Cat#: 412778

Name: CGS-7181

CAS#: 200345-93-3

Chemical Formula: C20H17F3N2O4

Exact Mass: 406.1140

Molecular Weight: 406.36

Elemental Analysis: C, 59.11; H, 4.22; F, 14.03; N, 6.89; O, 15.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
CGS-7181; CGS7181; CGS 7181
IUPAC/Chemical Name
1H-Indole-3-carboxylic acid, 1-(((4-methylphenyl)amino)carbonyl)-2-hydroxy-6-(trifluoromethyl)-, ethyl ester
InChi Key
YMEXYIFTFLKKQK-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H17F3N2O4/c1-3-29-18(27)16-14-9-6-12(20(21,22)23)10-15(14)25(17(16)26)19(28)24-13-7-4-11(2)5-8-13/h4-10,26H,3H2,1-2H3,(H,24,28)
SMILES Code
O=C(C1=C(O)N(C(NC2=CC=C(C)C=C2)=O)C3=C1C=CC(C(F)(F)F)=C3)OCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 406.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Augustynek B, Koprowski P, Rotko D, Kunz WS, Szewczyk A, Kulawiak B. Mitochondrial BK Channel Openers CGS7181 and CGS7184 Exhibit Cytotoxic Properties. Int J Mol Sci. 2018 Jan 25;19(2):353. doi: 10.3390/ijms19020353. PMID: 29370072; PMCID: PMC5855575. 2: Debska-Vielhaber G, Godlewski MM, Kicinska A, Skalska J, Kulawiak B, Piwonska M, Zablocki K, Kunz WS, Szewczyk A, Motyl T. Large-conductance K+ channel openers induce death of human glioma cells. J Physiol Pharmacol. 2009 Dec;60(4):27-36. PMID: 20065494.