Alestramustine is a cytostatic antineoplastic agent. It is the L-alanine ester of estramustine, which is a combination of the nitrogen mustard normustine coupled via a carbamate to the estrogen estradiol.Alestramustine acts as a prodrug to estramustine, and also forms estradiol as a byproduct.The drug, via its active metabolites, binds to microtubule-associated proteins and β-tubulin and interferes with microtubule function, thereby inhibiting cell division. Due to its estrogen moiety, alestramustine is selectively concentrated in estrogen receptor-positive cells such as prostate and breast.
MedKoo Cat#: 592519
Name: Alestramustine
CAS#: 139402-18-9
Chemical Formula: C26H36Cl2N2O4
Exact Mass: 510.2052
Molecular Weight: 511.48
Elemental Analysis: C, 61.05; H, 7.09; Cl, 13.86; N, 5.48; O, 12.51
The following data is based on the product molecular weight 511.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
