MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 529610 | Name: Tipelukast

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tipelukast, also known as KCA-757 and MN-001, is a leukotriene (LT) receptor antagonist potentially for the treatment of non-alcoholic fatty liver disease.

Chemical Structure

Tipelukast
CAS#125961-82-2

Theoretical Analysis

MedKoo Cat#: 529610

Name: Tipelukast

CAS#: 125961-82-2

Chemical Formula: C29H38O7S

Exact Mass: 530.2338

Molecular Weight: 530.67

Elemental Analysis: C, 65.64; H, 7.22; O, 21.10; S, 6.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
KCA-757; MN-001; KCA757; MN001; KCA 757; MN 001
IUPAC/Chemical Name
4-(6-acetyl-3-(3-((4-acetyl-3-hydroxy-2-propylphenyl)thio)propoxy)-2-propylphenoxy)butanoic acid
InChi Key
KPWYNAGOBXLMSE-UHFFFAOYSA-N
InChi Code
InChI=1S/C29H38O7S/c1-5-9-23-25(14-12-22(20(4)31)29(23)36-16-7-11-27(32)33)35-17-8-18-37-26-15-13-21(19(3)30)28(34)24(26)10-6-2/h12-15,34H,5-11,16-18H2,1-4H3,(H,32,33)
SMILES Code
O=C(O)CCCOC1=C(C(C)=O)C=CC(OCCCSC2=CC=C(C(C)=O)C(O)=C2CCC)=C1CCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 530.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: MN 001: KCA 757, KCA-757, MN-001. Drugs R D. 2007;8(6):400-2. PubMed PMID: 17963431. 2: Fujimura M, Ishiura Y, Amemiya T, Myou S, Matsuda T. No involvement of lipid mediators in a guinea pig model of ultrasonically nebulized distilled water-induced bronchoconstriction. Prostaglandins Other Lipid Mediat. 2000 Jan;60(1-3):49-58. PubMed PMID: 10680775. 3: Rajasekaran M, Locke KW, Parsons CL. MN-001, a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat model. BJU Int. 2006 Aug;98(2):430-4. PubMed PMID: 16879690. 4: Yamada TK, Bischoff MM, Heijnen GM, Mizoguchi T, Van Kempen H. Observation of spin-polarized surface states on ultrathin bct Mn(001) films by spin-polarized scanning tunneling spectroscopy. Phys Rev Lett. 2003 Feb 7;90(5):056803. PubMed PMID: 12633385. 5: Bagrets A, Schmaus S, Jaafar A, Kramczynski D, Yamada TK, Alouani M, Wulfhekel W, Evers F. Single molecule magnetoresistance with combined antiferromagnetic and ferromagnetic electrodes. Nano Lett. 2012 Oct 10;12(10):5131-6. doi: 10.1021/nl301967t. PubMed PMID: 22989203. 6: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2005 Jun;27(5):331-72. PubMed PMID: 16082422.