MedKoo Cat#: 463679 | Name: VH 032 amide-alkylC3-amine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VH 032 amide-alkylC3-amine is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC® research and development. It incorporates an E3 ligase ligand plus an alkyl C3 linker and terminal amine ready for conjugation to a target protein ligand. It is part of a range of functionalized tool molecules for PROTAC R&D.

Chemical Structure

VH 032 amide-alkylC3-amine
VH 032 amide-alkylC3-amine
CAS#2564467-25-8

Theoretical Analysis

MedKoo Cat#: 463679

Name: VH 032 amide-alkylC3-amine

CAS#: 2564467-25-8

Chemical Formula: C26H39Cl2N5O4S

Exact Mass: 587.2100

Molecular Weight: 588.59

Elemental Analysis: C, 53.06; H, 6.68; Cl, 12.05; N, 11.90; O, 10.87; S, 5.45

Price and Availability

Size Price Availability Quantity
25mg USD 500.00 2 Weeks
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Synonym
VH 032 amide-alkylC3-amine; VH032 amide-alkylC3-amine; VH-032 amide-alkylC3-amine;
IUPAC/Chemical Name
(2S,4R)-1-((S)-2-(4-aminobutanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
InChi Key
WMBHSWGXRVCMQP-YEMZLKFISA-N
InChi Code
InChI=1S/C26H37N5O4S.2ClH/c1-16-22(36-15-29-16)18-9-7-17(8-10-18)13-28-24(34)20-12-19(32)14-31(20)25(35)23(26(2,3)4)30-21(33)6-5-11-27;;/h7-10,15,19-20,23,32H,5-6,11-14,27H2,1-4H3,(H,28,34)(H,30,33);2*1H/t19-,20+,23-;;/m1../s1
SMILES Code
CC1=C(SC=N1)C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCN)=O)C(C)(C)C)=O)=O)C=C2.Cl.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 588.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL