VGTI-A3-03 | CAS#unknown | DENV serotype 2 antiviral agent

MedKoo Cat#: 463807 | Name: VGTI-A3-03

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VGTI-A3-03 is a highly virus-specific antiviral agent, with greatest activity against DENV serotype 2, directly binding dengue virus capsid protein.

Chemical Structure

VGTI-A3-03

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463807

Name: VGTI-A3-03

CAS#: unknown

Chemical Formula: C26H21N5OS2

Exact Mass: 483.1188

Molecular Weight: 483.61

Elemental Analysis: C, 64.57; H, 4.38; N, 14.48; O, 3.31; S, 13.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

VGTI-A3-03; VGTIA3-03; VGTI A3-03; VGTI-A303; VGTI-A3 03; VGTIA303; VGTI A3 03;

IUPAC/Chemical Name

3-amino-6-phenyl-N-(4-phenylthiazol-2-yl)-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide

InChi Key

NUJWCIKMMZQRHA-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H21N5OS2/c27-22-19-13-17-14-31(18-9-5-2-6-10-18)12-11-20(17)28-25(19)34-23(22)24(32)30-26-29-21(15-33-26)16-7-3-1-4-8-16/h1-10,13,15H,11-12,14,27H2,(H,29,30,32)

SMILES Code

O=C(C1=C(N)C2=CC3=C(N=C2S1)CCN(C4=CC=CC=C4)C3)NC5=NC(C6=CC=CC=C6)=CS5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 483.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Smith JL, Sheridan K, Parkins CJ, Frueh L, Jemison AL, Strode K, Dow G, Nilsen A, Hirsch AJ. Characterization and structure-activity relationship analysis of a class of antiviral compounds that directly bind dengue virus capsid protein and are incorporated into virions. Antiviral Res. 2018 Jul;155:12-19. doi: 10.1016/j.antiviral.2018.04.019. Epub 2018 Apr 27. PMID: 29709563.