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MedKoo Cat#: 575451 | Name: Fimasartan potassium anhydrous

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fimasartan potassium anhydrous is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure.

Chemical Structure

Fimasartan potassium anhydrous
Fimasartan potassium anhydrous
CAS#1402813-38-0 (potassium)

Theoretical Analysis

MedKoo Cat#: 575451

Name: Fimasartan potassium anhydrous

CAS#: 1402813-38-0 (potassium)

Chemical Formula: C27H30KN7OS

Exact Mass: 539.1870

Molecular Weight: 539.74

Elemental Analysis: C, 60.08; H, 5.60; K, 7.24; N, 18.17; O, 2.96; S, 5.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1020110-23-9 (potassium trihydrate) 247257-48-3 (free) 1402813-38-0 (potassium)
Synonym
Fimasartan potassium anhydrous
IUPAC/Chemical Name
5-Pyrimidineethanethioamide, 2-butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-((2'-(2H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, potassium salt (1:1)
InChi Key
OCKQGXSJNJCCDO-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H30N7OS.K/c1-5-6-11-24-28-18(2)23(16-25(36)33(3)4)27(35)34(24)17-19-12-14-20(15-13-19)21-9-7-8-10-22(21)26-29-31-32-30-26;/h7-10,12-15H,5-6,11,16-17H2,1-4H3;/q-1;+1
SMILES Code
[K+].CCCCC1=NC(=C(CC(=S)N(C)C)C(=O)N1Cc2ccc(cc2)c3ccccc3c4nnn[n-]4)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 539.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kim CK, Yang XL, Kim YJ, Choi IY, Jeong HG, Park HK, Kim D, Kim TJ, Jang H, Ko SB, Yoon BW. Effect of Long-Term Treatment with Fimasartan on Transient Focal Ischemia in Rat Brain. Biomed Res Int. 2015;2015:295925. doi: 10.1155/2015/295925. Epub 2015 Sep 13. PubMed PMID: 26448932; PubMed Central PMCID: PMC4584036. 2: Ghim JL, Paik SH, Hasanuzzaman M, Chi YH, Choi HK, Kim DH, Shin JG. Absolute bioavailability and pharmacokinetics of the angiotensin II receptor antagonist fimasartan in healthy subjects. J Clin Pharmacol. 2015 Aug 13. doi: 10.1002/jcph.618. [Epub ahead of print] PubMed PMID: 26272450. 3: Rhee MY, Baek SH, Kim W, Park CG, Park SW, Oh BH, Kim SH, Kim JJ, Shin JH, Yoo BS, Rim SJ, Ha JW, Doh JH, Ahn Y, Chae JK, Park JB, Kim SK, Kim CH. Efficacy of fimasartan/hydrochlorothiazide combination in hypertensive patients inadequately controlled by fimasartan monotherapy. Drug Des Devel Ther. 2015 Jun 2;9:2847-54. doi: 10.2147/DDDT.S82098. eCollection 2015. PubMed PMID: 26082615; PubMed Central PMCID: PMC4459623.