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MedKoo Cat#: 584271 | Name: Brocrinat

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Brocrinat, also known as HP 522, is an active saluretic and has at least one site of action in the medullary ascending limb of Henle's loop; N1 from CA Vol 92 Form Index.

Chemical Structure

Brocrinat
Brocrinat
CAS#72481-99-3

Theoretical Analysis

MedKoo Cat#: 584271

Name: Brocrinat

CAS#: 72481-99-3

Chemical Formula: C15H9BrFNO4

Exact Mass: 364.9699

Molecular Weight: 366.14

Elemental Analysis: C, 49.21; H, 2.48; Br, 21.82; F, 5.19; N, 3.83; O, 17.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Brocrinat; HP 522;
IUPAC/Chemical Name
Acetic acid, ((7-bromo-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)-
InChi Key
QWOLGQYXAQSNAE-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H9BrFNO4/c16-13-11(21-7-12(19)20)6-5-9-14(18-22-15(9)13)8-3-1-2-4-10(8)17/h1-6H,7H2,(H,19,20)
SMILES Code
O=C(O)COC1=C(Br)C2=C(C=C1)C(C3=CC=CC=C3F)=NO2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 366.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kitzen JM, Schwenkler MA, Bixby PR, Wilson SJ, Shutske G, Setescak L, Allen R, Rosenblum I. Characterization of the renal pharmacology of HP-522, a loop diuretic with uricosuric activity. Life Sci. 1980 Dec 22-29;27(25-26):2547-52. PubMed PMID: 7219027. 2: Shutske GM, Setescak LL, Allen RC, Davis L, Effland RC, Ranbom K, Kitzen JM, Wilker JC, Novick WJ Jr. [(3-aryl-1,2-benzisoxazol-6-yl)oxy]acetic acids. A new diuretic series. J Med Chem. 1982 Jan;25(1):36-44. PubMed PMID: 7086820.