Zaldaride (free base) | CAS #109826-26-8 (free base) | Antidiarrheals

MedKoo Cat#: 412755 | Name: Zaldaride (free base)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Zaldaride (free base) is a calmodulin antagonist.

Chemical Structure

Zaldaride (free base)

CAS#109826-26-8 (free base)

Theoretical Analysis

MedKoo Cat#: 412755

Name: Zaldaride (free base)

CAS#: 109826-26-8 (free base)

Chemical Formula: C26H28N4O2

Exact Mass: 428.2212

Molecular Weight: 428.54

Elemental Analysis: C, 72.87; H, 6.59; N, 13.07; O, 7.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

109826-26-8 (free base) 109826-27-9 (maleate)

Synonym

Zaldaride (free base); CGS9343B; CGS-9343B; CGS 9343B

IUPAC/Chemical Name

(+-)-1-(1-((4-Methyl-4H,6H-pyrrolo(1,2-a)(4,1)benzoxazepin-4-yl)methyl)-4-piperidyl)-2-benzimidazolinone

InChi Key

GTJCOJYEIQLGNQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H27N4O2/c1-23(15-24-19-7-3-2-6-17(19)14-29-23)16-26-12-10-18(11-13-26)27-21-9-5-4-8-20(21)25-22(27)28/h2-9,18H,10-16H2,1H3,(H,25,28)

SMILES Code

O=C1NC2=CC=CC=C2N1C3CCN(CC4(C)C[N]C5=CC=CC=C5CO4)CC3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 428.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Powlin SS, Keng PC, Miller RK. Toxicity of cadmium in human trophoblast cells (JAr choriocarcinoma): role of calmodulin and the calmodulin inhibitor, zaldaride maleate. Toxicol Appl Pharmacol. 1997 Jun;144(2):225-34. doi: 10.1006/taap.1997.8135. PMID: 9194406. 2: Okhuysen PC, DuPont HL, Ericsson CD, Marani S, Martinez-Sandoval FG, Olesen MA, Ravelli GP. Zaldaride maleate (a new calmodulin antagonist) versus loperamide in the treatment of traveler's diarrhea: randomized, placebo- controlled trial. Clin Infect Dis. 1995 Aug;21(2):341-4. doi: 10.1093/clinids/21.2.341. PMID: 8562742. 3: Silberschmidt G, Schick MT, Steffen R, Kilpatrick ME, Murphy JR, Oyofo BA, el-Etr S, Gyurech D, Mourad AS, Mathewson JT, et al. Treatment of travellers' diarrhoea: zaldaride compared with loperamide and placebo. Eur J Gastroenterol Hepatol. 1995 Sep;7(9):871-5. PMID: 8574720. 4: Aikawa N, Karasawa A, Ohmori K. Effect of zaldaride maleate, an antidiarrheal compound, on 16,16-dimethyl prostaglandin E2-induced intestinal ion secretion in rats. Jpn J Pharmacol. 2000 Jul;83(3):269-72. doi: 10.1254/jjp.83.269. PMID: 10952078. 5: Aikawa N, Ohmori K. Effect of zaldaride maleate, an antidiarrheal compound, on fecal pellet output induced by hyperpropulsion in gastrointestine of rats. Jpn J Pharmacol. 2000 Apr;82(4):350-2. doi: 10.1254/jjp.82.350. PMID: 10875756. 6: Aikawa N, Horikoshi K, Maeda H, Kobayashi H, Ohmori K. Antidiarrheal effects of zaldaride maleate after oral, intravenous and subcutaneous administration to rats. Jpn J Pharmacol. 1999 Dec;81(4):397-400. doi: 10.1254/jjp.81.397. PMID: 10669047. 7: Aikawa N, Horikoshi K, Maeda H, Kobayashi H, Ohmori K. Comparison of the antidiarrheal effects of zaldaride maleate and its optical isomers in rats. Biol Pharm Bull. 2000 Apr;23(4):402-5. doi: 10.1248/bpb.23.402. PMID: 10784416. 8: Ericsson CD. Travellers' diarrhoea. Int J Antimicrob Agents. 2003 Feb;21(2):116-24. doi: 10.1016/s0924-8579(02)00282-0. PMID: 12615374. 9: Aikawa N, Kishibayashi N, Karasawa A, Ohmori K. The effect of zaldaride maleate, an antidiarrheal compound, on acetylcholine-induced intestinal electrolyte secretion. Biol Pharm Bull. 2000 Nov;23(11):1377-8. doi: 10.1248/bpb.23.1377. PMID: 11085370. 10: Aikawa N, Karasawa A. Effects of KW-5617 (zaldaride maleate), a potent and selective calmodulin inhibitor, on secretory diarrhea and on gastrointestinal propulsion in rats. Jpn J Pharmacol. 1998 Feb;76(2):199-206. doi: 10.1254/jjp.76.199. PMID: 9541283.