MedKoo Cat#: 575448 | Name: Fiduxosin hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fiduxosin hydrochloride is an alpha 1a-adrenoceptor antagonist that may be useful in the treatment of Benign Prostatic Hyperplasia.

Chemical Structure

Fiduxosin hydrochloride
Fiduxosin hydrochloride
CAS#208992-74-9

Theoretical Analysis

MedKoo Cat#: 575448

Name: Fiduxosin hydrochloride

CAS#: 208992-74-9

Chemical Formula: C30H30ClN5O4S

Exact Mass: 591.1707

Molecular Weight: 592.11

Elemental Analysis: C, 60.86; H, 5.11; Cl, 5.99; N, 11.83; O, 10.81; S, 5.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
A-185980.1; ABT-980; ABT 980; ABT980; Fiduxosin hydrochloride; Fiduxosin HCl
IUPAC/Chemical Name
pyrazino(2',3':4,5)thieno(3,2-d)pyrimidine-2,4(1h,3h)-dione, 8-phenyl-3-(4-((3ar,9br)-1,3a,4,9b-tetrahydro-9-methoxy(1)benzopyrano(3,4-c)pyrrol-2(3h)-yl)butyl)-,monohydrochloride
InChi Key
OFPMGRPQOZABPO-GZJHNZOKSA-N
InChi Code
InChI=1S/C30H29N5O4S.ClH/c1-38-22-10-7-11-23-24(22)20-16-34(15-19(20)17-39-23)12-5-6-13-35-29(36)27-25(33-30(35)37)26-28(40-27)31-14-21(32-26)18-8-3-2-4-9-18;/h2-4,7-11,14,19-20H,5-6,12-13,15-17H2,1H3,(H,33,37);1H/t19-,20-;/m1./s1
SMILES Code
Cl.COc1cccc2OC[C@H]3CN(CCCCN4C(=O)Nc5c(sc6ncc(nc56)c7ccccc7)C4=O)C[C@H]3c12
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 592.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Colanesi S, Taylor KL, Temperley ND, Lundegaard PR, Liu D, North TE, Ishizaki H, Kelsh RN, Patton EE. Small molecule screening identifies targetable zebrafish pigmentation pathways. Pigment Cell Melanoma Res. 2012 Mar;25(2):131-43. doi:10.1111/j.1755-148X.2012.00977.x. PubMed PMID: 22252091. 2: Dutta S, Zhang Y, Daszkowski DJ, Granneman GR, Verlinden M. Single- and multiple-dose pharmacokinetics of fiduxosin under nonfasting conditions in healthy male subjects. J Clin Pharmacol. 2002 May;42(5):540-6. PubMed PMID: 12017348. 3: Dutta S, Zhang Y, Daszkowski DJ, Granneman GR, Verlinden M. Multiple dose pharmacokinetics of fiduxosin under fasting conditions in healthy elderly male subjects. J Pharm Pharmacol. 2002 May;54(5):641-7. PubMed PMID: 12005359.