MedKoo Cat#: 462974 | Name: CAY10746
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CAY10746 is an inhibitor of Rho-associated kinase I (ROCK-I) and ROCK-II. It is selective for ROCK-I and ROCK-II over PKA and over 387 recombinant human protein kinases in a panel of 394 kinases but does inhibit LIM kinase 2, Aurora A, Aurora B, cGMP-dependent protein kinase 1α, and PKG1β. CAY10746 inhibits phosphorylation of the ROCK target protein MYPT1 in SH-SY5Y cells. It also inhibits migration of human umbilical vein endothelial cells when used at a concentration of 1 µM. CAY10746 protects isolated mouse retinal neurons from apoptosis and oxidative stress induced by high glucose in an in vitro model of diabetic retinopathy. It also promotes high glucose-induced vessel regression in mouse retinal explants.

Chemical Structure

CAY10746
CAY10746
CAS#2247240-76-0

Theoretical Analysis

MedKoo Cat#: 462974

Name: CAY10746

CAS#: 2247240-76-0

Chemical Formula: C26H23N3O5

Exact Mass: 457.1638

Molecular Weight: 457.49

Elemental Analysis: C, 68.26; H, 5.07; N, 9.19; O, 17.49

Price and Availability

Size Price Availability Quantity
1mg USD 550.00 2 Weeks
5mg USD 1,250.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
CAY10746; CAY 10746; CAY-10746;
IUPAC/Chemical Name
4-(dimethylamino)-N-(3-(2-((4-oxo-4H-chromen-7-yl)oxy)acetamido)phenyl)benzamide
InChi Key
WVGDUQVQWLHVEA-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H23N3O5/c1-29(2)20-8-6-17(7-9-20)26(32)28-19-5-3-4-18(14-19)27-25(31)16-34-21-10-11-22-23(30)12-13-33-24(22)15-21/h3-15H,16H2,1-2H3,(H,27,31)(H,28,32)
SMILES Code
CN(C1=CC=C(C=C1)C(NC2=CC=CC(NC(COC3=CC(OC=C4)=C(C=C3)C4=O)=O)=C2)=O)C
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 457.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL