CAY10746 is an inhibitor of Rho-associated kinase I (ROCK-I) and ROCK-II. It is selective for ROCK-I and ROCK-II over PKA and over 387 recombinant human protein kinases in a panel of 394 kinases but does inhibit LIM kinase 2, Aurora A, Aurora B, cGMP-dependent protein kinase 1α, and PKG1β. CAY10746 inhibits phosphorylation of the ROCK target protein MYPT1 in SH-SY5Y cells. It also inhibits migration of human umbilical vein endothelial cells when used at a concentration of 1 µM. CAY10746 protects isolated mouse retinal neurons from apoptosis and oxidative stress induced by high glucose in an in vitro model of diabetic retinopathy. It also promotes high glucose-induced vessel regression in mouse retinal explants.
MedKoo Cat#: 462974
Name: CAY10746
CAS#: 2247240-76-0
Chemical Formula: C26H23N3O5
Exact Mass: 457.1638
Molecular Weight: 457.49
Elemental Analysis: C, 68.26; H, 5.07; N, 9.19; O, 17.49
The following data is based on the product molecular weight 457.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |