MedKoo Cat#: 555897 | Name: DFN75624
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

DFN75624 is a dengue viral replication inhibitor. DFN75624 was first reported in patent WO 2018215315 (Janssen Pharmaceuticals). This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

DFN75624
CAS#2253675-62-4 (S-isomer)

Theoretical Analysis

MedKoo Cat#: 555897

Name: DFN75624

CAS#: 2253675-62-4 (S-isomer)

Chemical Formula: C29H26ClF3N2O6

Exact Mass: 590.1431

Molecular Weight: 590.98

Elemental Analysis: C, 58.94; H, 4.43; Cl, 6.00; F, 9.64; N, 4.74; O, 16.24

Price and Availability

Size Price Availability Quantity
100mg USD 6,950.00 2 Weeks
200mg USD 9,650.00 2 Weeks
500mg USD 14,950.00 2 Weeks
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Related CAS #
2253675-60-2 (racemic) 2253675-61-3 (R-isomer) 2253675-62-4 (S-isomer)
Synonym
DFN75624; DFN-75624; DFN 75624; DENV-IN-2;
IUPAC/Chemical Name
(1R,2R)-2-((3-(((S)-1-(4-chlorophenyl)-2-oxo-2-(6-(trifluoromethoxy)indolin-1-yl)ethyl)amino)-5-methoxyphenoxy)methyl)cyclopropane-1-carboxylic acid
InChi Key
DPLSNZRPHADTGY-FODJJAHYSA-N
InChi Code
InChI=1S/C29H26ClF3N2O6/c1-39-22-11-20(12-23(13-22)40-15-18-10-24(18)28(37)38)34-26(17-2-5-19(30)6-3-17)27(36)35-9-8-16-4-7-21(14-25(16)35)41-29(31,32)33/h2-7,11-14,18,24,26,34H,8-10,15H2,1H3,(H,37,38)/t18-,24+,26-/m0/s1
SMILES Code
O=C([C@@H](NC1=CC(OC[C@@H]2C[C@H]2C(O)=O)=CC(OC)=C1)C3=CC=C(Cl)C=C3)N4CCC5=CC=C(OC(F)(F)F)C=C54
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM comments
Solubility
Soluble in DMSO 0.0 0.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 590.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Preparation of substituted indoline derivatives as dengue viral replication inhibitors By: Bonfanti, Jean-Francois; Kesteleyn, Bart Rudolf Romanie; Bardiot, Dorothee Alice Marie-Eve; Marchand, Arnaud Didier M.; Coesemans, Erwin; Fortin, Jerome Michel Claude; Mercey, Guillaume Jean Maurice; Raboisson, Pierre Jean-Marie Bernard. Assignee: Janssen Pharmaceuticals, Inc., USA; Katholieke Universiteit Leuven. From: PCT Int. Appl., 2018215315, 29 Nov 2018