Synonym
Prenalterol hydrochloride; CGP7760B; CGP-7760B; CGP 7760B
IUPAC/Chemical Name
(S)-4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)phenol hydrochloride
InChi Key
WDXYIFGETVGLBZ-MERQFXBCSA-N
InChi Code
InChI=1S/C12H19NO3.ClH/c1-9(2)13-7-11(15)8-16-12-5-3-10(14)4-6-12;/h3-6,9,11,13-15H,7-8H2,1-2H3;1H/t11-;/m0./s1
SMILES Code
OC1=CC=C(OC[C@@H](O)CNC(C)C)C=C1.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
261.75
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Glover DR, Wathen CG, Murray RG, Petch MC, Muir AL, Littler WA. Are the clinical benefits of oral prenalterol in ischaemic heart failure due to beta blockade? A six month randomised double blind comparison with placebo. Br Heart J. 1985 Feb;53(2):208-15. doi: 10.1136/hrt.53.2.208. PMID: 2857088; PMCID: PMC481741.
2: Jennings G, Bobik A, Oddie C, Hargreaves M, Korner P. Cardioselectivity of prenalterol and isoproterenol. Clin Pharmacol Ther. 1983 Dec;34(6):749-57. doi: 10.1038/clpt.1983.245. PMID: 6641090.
3: Silke B, Hanratty CG, Riddell JG. Heart-rate variability effects of beta- adrenoceptor agonists (xamoterol, prenalterol, and salbutamol) assessed nonlinearly with scatterplots and sequence methods. J Cardiovasc Pharmacol. 1999 Jun;33(6):859-67. doi: 10.1097/00005344-199906000-00005. PMID: 10367588.
4: Aly FA. Spectrofluorimetric determination of prenalterol hydrochloride in pharmaceutical preparations and biological fluids. J Pharm Biomed Anal. 1999 Jan;18(6):993-7. doi: 10.1016/s0731-7085(98)00108-3. PMID: 9925334.
5: Kendall MJ, Goodfellow RM, Westerling S. Prenalterol--a new cardioselective inotropic agent. J Clin Hosp Pharm. 1982 Jun;7(2):107-18. doi: 10.1111/j.1365-2710.1982.tb01010.x. PMID: 7050180.
6: Mattsson H, Hedberg A, Carlsson E. Intrinsic sympathomimetic activity of the partial agonist prenalterol in relation to beta adrenoceptor interaction in various tissues, in vitro. J Pharmacol Exp Ther. 1983 Mar;224(3):654-61. PMID: 6131123.
7: McCaffrey PM, Riddell JG, Shanks RG. The selectivity of xamoterol, prenalterol, and salbutamol as assessed by their effects in the presence and absence of ICI 118,551. J Cardiovasc Pharmacol. 1988 May;11(5):543-51. doi: 10.1097/00005344-198805000-00006. PMID: 2455840.
8: Capucci A, Frabetti L, Melandri G, Magnani B. Electrophysiologic properties of prenalterol. Int J Cardiol. 1983;2(3-4):391-400. doi: 10.1016/0167-5273(83)90011-6. PMID: 6132888.
9: Löfdahl CG, Svedmyr N. Effect of prenalterol in asthmatic patients. Eur J Clin Pharmacol. 1982 Oct;23(4):297-302. doi: 10.1007/BF00613609. PMID: 6129142.
10: Sharpe DN, Coxon R. Prenalterol, an oral beta-1 adrenoceptor agonist, in the treatment of chronic heart failure. Eur J Clin Pharmacol. 1983;25(4):539-45. doi: 10.1007/BF00542125. PMID: 6653650.
