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MedKoo Cat#: 461126 | Name: Prenalterol (free base)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Prenalterol (free base) is a selective inotropic beta-adrenoceptor agonist. It is used as a cardiac stimulant.

Chemical Structure

Prenalterol (free base)
CAS#62340-37-8 (free base)

Theoretical Analysis

MedKoo Cat#: 461126

Name: Prenalterol (free base)

CAS#: 62340-37-8 (free base)

Chemical Formula: C12H19NO3

Exact Mass: 225.1365

Molecular Weight: 225.28

Elemental Analysis: C, 63.98; H, 8.50; N, 6.22; O, 21.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
61260-05-7 (HCl) 62340-37-8 (free base)
Synonym
Prenalterol; H 80/62; H-80/62; H80/62;
IUPAC/Chemical Name
(R)-4-(2-hydroxy-3-(isopropylamino)propoxy)phenol
InChi Key
ADUKCCWBEDSMEB-LLVKDONJSA-N
InChi Code
InChI=1S/C12H19NO3/c1-9(2)13-7-11(15)8-16-12-5-3-10(14)4-6-12/h3-6,9,11,13-15H,7-8H2,1-2H3/t11-/m1/s1
SMILES Code
CC(C)NC[C@@H](O)COc1ccc(O)cc1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 225.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Löfdahl CG, Svedmyr N. Effect of prenalterol in asthmatic patients. Eur J Clin Pharmacol. 1982 Oct;23(4):297-302. PubMed PMID: 6129142. 2: Fitzpatrick D, Ikram H, Nicholls MG, Espiner EA. Hemodynamic, hormonal and electrolyte responses to prenalterol infusion in heart failure. Circulation. 1983 Mar;67(3):613-9. PubMed PMID: 6821903. 3: Silke B, Hanratty CG, Riddell JG. Heart-rate variability effects of beta-adrenoceptor agonists (xamoterol, prenalterol, and salbutamol) assessed nonlinearly with scatterplots and sequence methods. J Cardiovasc Pharmacol. 1999 Jun;33(6):859-67. PubMed PMID: 10367588. 4: Wirtzfeld A, Klein G, Bibra HV, Sauer E. Prenalterol: a partial beta 1-adrenoceptor agonist or a beta-blocker with intrinsic activity? Int J Clin Pharmacol Ther Toxicol. 1985 Jan;23(1):20-7. PubMed PMID: 2859252. 5: Jennings G, Bobik A, Oddie C, Hargreaves M, Korner P. Cardioselectivity of prenalterol and isoproterenol. Clin Pharmacol Ther. 1983 Dec;34(6):749-57. PubMed PMID: 6641090. 6: Greefhorst AP, van Herwaarden CL. Ventilatory and haemodynamic effects of prenalterol and terbutaline in asthmatic patients. Eur J Clin Pharmacol. 1983;24(2):173-8. PubMed PMID: 6132819. 7: Gurden JM, Apperley GH, Drew GM. A comparison of the properties of prenalterol and corwin at beta 1- and beta 2-adrenoreceptors in vitro. J Auton Pharmacol. 1989 Apr;9(2):79-91. PubMed PMID: 2565903. 8: Moore EN, Aberg G, Spear JF, Hodess AB, Herrmann I, Adler G. Inotropic, chronotropic and dromotropic effects of prenalterol, a new cardiostimulant drug. Acta Med Scand Suppl. 1982;659:53-70. PubMed PMID: 6958179. 9: Svendsen TL, Pelle H, Lønholt C, Bonde J, Kampmann JP, Lindeneg O. A comparison of the hemodynamic effects of prenalterol and isoprenaline in patients with complete heart block. J Cardiovasc Pharmacol. 1984 Jul-Aug;6(4):693-6. PubMed PMID: 6206327. 10: Kenakin TP, Beek D. Relative efficacy of prenalterol and pirbuterol for beta-1 adrenoceptors: measurement of agonist affinity by alteration of receptor number. J Pharmacol Exp Ther. 1984 May;229(2):340-5. PubMed PMID: 6143816. 11: Mattsson H, Hedberg A, Carlsson E. Intrinsic sympathomimetic activity of the partial agonist prenalterol in relation to beta adrenoceptor interaction in various tissues, in vitro. J Pharmacol Exp Ther. 1983 Mar;224(3):654-61. PubMed PMID: 6131123. 12: Hoffmann KJ, Arfwidsson A, Borg KO. The metabolic disposition of the selective beta 1-adrenoceptor agonist prenalterol in mice, rats, dogs, and humans. Drug Metab Dispos. 1982 Mar-Apr;10(2):173-9. PubMed PMID: 6124405. 13: O'Donnell JM. Effects of clenbuterol and prenalterol on behavior maintained under a multiple fixed-interval, fixed-ratio schedule. J Pharmacol Exp Ther. 1987 Aug;242(2):588-94. PubMed PMID: 2886645. 14: Goovaerts J, Verfaillie C, Knockaert D, Fagard R, Fiocchi R, Amery A, Lijnen P. Prenalterol in the treatment of orthostatic hypotension in Shy-Drager syndrome. Acta Cardiol. 1984;39(2):147-55. PubMed PMID: 6145274. 15: Kenakin TP, Beek D. The measurement of the relative efficacy of agonists by selective potentiation of tissue responses: studies with isoprenaline and prenalterol in cardiac tissue. J Auton Pharmacol. 1984 Sep;4(3):153-9. PubMed PMID: 6208197. 16: Aass H, Skomedal T, Osnes JB. Increase of cyclic AMP in subcellular fractions of rat heart muscle after beta-adrenergic stimulation: prenalterol and isoprenaline caused different distribution of bound cyclic AMP. J Mol Cell Cardiol. 1988 Sep;20(9):847-60. PubMed PMID: 2852724. 17: Wohlfart B, Khan AR. Analysis of the inotropic effect of prenalterol in papillary muscles from guinea-pig hearts. Acta Physiol Scand. 1987 Jun;130(2):187-91. PubMed PMID: 3604708. 18: McCaffrey PM, Riddell JG, Shanks RG. The selectivity of xamoterol, prenalterol, and salbutamol as assessed by their effects in the presence and absence of ICI 118,551. J Cardiovasc Pharmacol. 1988 May;11(5):543-51. PubMed PMID: 2455840. 19: Sharpe DN, Coxon R. Prenalterol, an oral beta-1 adrenoceptor agonist, in the treatment of chronic heart failure. Eur J Clin Pharmacol. 1983;25(4):539-45. PubMed PMID: 6653650. 20: Rohm N, Wagner J, Schümann HJ. The lack of a pronounced preference of prenalterol for the beta-l-adrenoceptor subtype. Naunyn Schmiedebergs Arch Pharmacol. 1980;315(1):85-8. PubMed PMID: 6113550.