Cetamolol (free base) | CAS# 34919-98-7 (free base) | beta adrenergic antagonist

MedKoo Cat#: 412594 | Name: Cetamolol (free base)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cetamolol (free base) is a beta adrenergic antagonist, more specifically a β₁-adrenergic blocker.

Chemical Structure

Cetamolol (free base)

CAS# 34919-98-7 (free base)

Theoretical Analysis

MedKoo Cat#: 412594

Name: Cetamolol (free base)

CAS#: 34919-98-7 (free base)

Chemical Formula: C16H26N2O4

Exact Mass: 310.1893

Molecular Weight: 310.39

Elemental Analysis: C, 61.91; H, 8.44; N, 9.03; O, 20.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

77590-95-5 (HCl) 34919-98-7 (free base)

Synonym

Cetamolol (free base); ICI72222; ICI-72222; ICI 72222

IUPAC/Chemical Name

Acetamide, 2-(2-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)phenoxy)-N-methyl-

InChi Key

UWCBNAVPISMFJZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H26N2O4/c1-16(2,3)18-9-12(19)10-21-13-7-5-6-8-14(13)22-11-15(20)17-4/h5-8,12,18-19H,9-11H2,1-4H3,(H,17,20)

SMILES Code

O=C(NC)COC1=CC=CC=C1OCC(O)CNC(C)(C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 310.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Beaulieu G, Grimes D, Muirhead C, Oshiro G. Cetamolol: cardiovascular effects of a new cardioselective beta-adrenoceptor blocker possessing partial agonistic activity and lacking membrane-stabilizing activity. Can J Physiol Pharmacol. 1984 Jun;62(6):610-6. doi: 10.1139/y84-098. PMID: 6146394. 2: Klausner MA, Ventura DF, Coelho J, Mullane JF, Irwin C, Hitzenberger G, Magometschnigg D, Kaik G, Garg DC, Weidler DJ. Cardioselectivity of cetamolol compared with atenolol and nadolol. J Clin Pharmacol. 1988 Jun;28(6):495-504. doi: 10.1002/j.1552-4604.1988.tb03166.x. PMID: 2901435. 3: Beaulieu G, Jaramillo J, Cummings JR. Cetamolol: a new cardioselective beta- adrenoceptor blocking agent without membrane-stabilizing activity. Can J Physiol Pharmacol. 1984 Mar;62(3):302-8. doi: 10.1139/y84-047. PMID: 6144380. 4: Coelho J, Schnelle K, Joubert L, Ventura D, Mullane J. Dynamics of beta- adrenoceptor blockade with cetamolol. Br J Clin Pharmacol. 1985 Apr;19(4):411-6. doi: 10.1111/j.1365-2125.1985.tb02663.x. PMID: 2859872; PMCID: PMC1463814. 5: White WB, Schulman P, McCabe EJ, Hager WD. Effects of chronic cetamolol therapy on resting, ambulatory, and exercise blood pressure and heart rate. Clin Pharmacol Ther. 1986 Jun;39(6):664-8. doi: 10.1038/clpt.1986.116. PMID: 3709031. 6: Rimele TJ, Henry DE, Giesa FR, Buckley SK, Geiger G, Heaslip RJ, Lee DK, Grimes D. Comparison of the beta-adrenoceptor affinity and selectivity of cetamolol, atenolol, betaxolol, and ICI-118,551. J Cardiovasc Pharmacol. 1988 Aug;12(2):208-17. doi: 10.1097/00005344-198808000-00011. PMID: 2459552. 7: Skoutakis VA, Acchiardo SA, Carter CA, Ingebretsen CG, Klausner MA, Lee DK, Kraml M. Pharmacokinetics of cetamolol in hypertensive patients with normal and compromised renal function. J Clin Pharmacol. 1988 May;28(5):467-76. doi: 10.1002/j.1552-4604.1988.tb05762.x. PMID: 2899095. 8: Klausner MA, Irwin C, Mullane JF, Shand DG, Leese PT, Arnold JD, Wollberg W, Wagner NB, Wagner GS. Effect of cetamolol on epinephrine-induced hypokalemia. J Clin Pharmacol. 1988 Aug;28(8):751-6. doi: 10.1002/j.1552-4604.1988.tb03210.x. PMID: 2905711. 9: Klein M, Stupienski RF, Nettler S, Smith T, Oshiro G. Comparison of the effects of cetamolol and atenolol on epinephrine- and isoproterenol-induced hypokalemia in anesthetized dogs. J Cardiovasc Pharmacol. 1989 Jan;13(1):118-24. PMID: 2468922. 10: White WB, Schulman P, McCabe EJ. Psoriasiform cutaneous eruptions induced by cetamolol hydrochloride. Arch Dermatol. 1986 Aug;122(8):857-8. PMID: 2874772.