MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 126092 | Name: Tigloidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tigloidine is a tropane alkaloid and a naturally occurring analog of atropine, found in small quantities in Duboisia myoporoides. Tigloidine has been found to be beneficial in the treatment of Parkinsonism, Huntington’s Chorea and spastic paraplegia.

Chemical Structure

Tigloidine
CAS#495-83-0 (free base)

Theoretical Analysis

MedKoo Cat#: 126092

Name: Tigloidine

CAS#: 495-83-0 (free base)

Chemical Formula: C13H21NO2

Exact Mass: 223.1572

Molecular Weight: 223.32

Elemental Analysis: C, 69.92; H, 9.48; N, 6.27; O, 14.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
495-83-0 (free base) 22846-83-9 (HBr)
Synonym
Tropigline; tigloidin; Tigloidine; 495-83-0; Tiglylpseudotropine;
IUPAC/Chemical Name
8-methyl-8-azabicyclo[3.2.1]octan-3-yl (E)-2-methylbut-2-enoate
InChi Key
UVHGSMZRSVGWDJ-RUDMXATFSA-N
InChi Code
InChI=1S/C13H21NO2/c1-4-9(2)13(15)16-12-7-10-5-6-11(8-12)14(10)3/h4,10-12H,5-8H2,1-3H3/b9-4+
SMILES Code
C/C=C(C(OC1CC2CCC(N2C)C1)=O)\C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 223.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: TRAUTNER EM, NOACK CH. Tigloidine as a substitute for atropine in the treatment of Parkinsonism. Med J Aust. 1951 May 26;1(21):751-4. doi: 10.5694/j.1326-5377.1951.tb56491.x. PMID: 14852182. 2: O'ROURKE FJ, GERSHON S, TRAUTNER EM, SHAW FH. The use of tigloidine in the symptomatic treatment of spastic paraplegia. Med J Aust. 1960 Jan 16;47(1):73-7. doi: 10.5694/j.1326-5377.1960.tb86940.x. PMID: 14428122. 3: Sanghvi I, Bindler E, Gershon S. Pharmacology of a potential anti-Parkinson agent: tigloidine. Eur J Pharmacol. 1968 Oct;4(3):246-53. doi: 10.1016/0014-2999(68)90091-5. PMID: 5723419. 4: TRAUTNER EM, GERSHON S. The effect of tigloidine on extrapyramidal syndromes (Huntington's chorea). Australas Ann Med. 1958 Nov;7(4):286-91. doi: 10.1111/imj.1958.7.4.286. PMID: 13607328.