AZD-3783 | CAS# 1162658-64-1 | Biochemical

MedKoo Cat#: 575154 | Name: AZD-3783

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZD-3783 is a selective 5-hydroxytryptamine 1B receptor antagonist with probable antidepressant and anxiolytic activity.

Chemical Structure

AZD-3783

CAS#1162658-64-1

Theoretical Analysis

MedKoo Cat#: 575154

Name: AZD-3783

CAS#: 1162658-64-1

Chemical Formula: C26H34N4O4

Exact Mass: 466.2580

Molecular Weight: 466.58

Elemental Analysis: C, 66.93; H, 7.35; N, 12.01; O, 13.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

AZD-3783; AZD3783; AZD 3783; Az-12320927(racemate)

IUPAC/Chemical Name

(2R)-6-Methoxy-8-(4-methylpiperazin-1-yl)-N-(4-morpholinophenyl)chromane-2-carboxamide

InChi Key

SKOWCFJEXPLGNE-XMMPIXPASA-N

InChi Code

InChI=1S/C26H34N4O4/c1-28-9-11-30(12-10-28)23-18-22(32-2)17-19-3-8-24(34-25(19)23)26(31)27-20-4-6-21(7-5-20)29-13-15-33-16-14-29/h4-7,17-18,24H,3,8-16H2,1-2H3,(H,27,31)/t24-/m1/s1

SMILES Code

COc1cc2CC[C@@H](Oc2c(c1)N3CCN(C)CC3)C(=O)Nc4ccc(cc4)N5CCOCC5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 466.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Zhang M, Zhou D, Wang Y, Maier DL, Widzowski DV, Sobotka-Briner CD, Brockel BJ, Potts WM, Shenvi AB, Bernstein PR, Pierson ME. Preclinical pharmacology and pharmacokinetics of AZD3783, a selective 5-hydroxytryptamine 1B receptor antagonist. J Pharmacol Exp Ther. 2011 Nov;339(2):567-78. doi: 10.1124/jpet.110.174433. Epub 2011 Aug 8. PMID: 21825000. 2. Varnäs K, Nyberg S, Karlsson P, Pierson ME, Kågedal M, Cselényi Z, McCarthy D, Xiao A, Zhang M, Halldin C, Farde L. Dose-dependent binding of AZD3783 to brain 5-HT1B receptors in non-human primates and human subjects: a positron emission tomography study with [11C]AZ10419369. Psychopharmacology (Berl). 2011 Feb;213(2-3):533-45. doi: 10.1007/s00213-011-2165-z. Epub 2011 Jan 15. PMID: 21234549. 3. Chang JC, Ciaccio P, Schroeder P, Wright L, Westwood R, Berg AL. Pathology and Neurotoxicity in Dogs after Repeat Dose Exposure to a Serotonin 5-HT1B Inhibitor. J Toxicol Pathol. 2014 Apr;27(1):31-42. doi: 10.1293/tox.2013-0033. Epub 2014 Apr 30. PMID: 24791065; PMCID: PMC4000071.