Fusidate Sodium | CAS# 751-94-0 | antibiotic

MedKoo Cat#: 412555 | Name: Fusidate Sodium

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fusidate Sodium is an antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis.

Chemical Structure

Fusidate Sodium

CAS#751-94-0 (sodium)

Theoretical Analysis

MedKoo Cat#: 412555

Name: Fusidate Sodium

CAS#: 751-94-0 (sodium)

Chemical Formula: C31H47NaO6

Exact Mass: 0.0000

Molecular Weight: 538.70

Elemental Analysis: C, 69.12; H, 8.79; Na, 4.27; O, 17.82

Price and Availability

Size	Price	Availability
250mg	USD 250.00	2 Weeks
1g	USD 550.00	2 Weeks
5g	USD 1,050.00	2 Weeks

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Related CAS #

751-94-0 (sodium) 16391-75-6 (diethanolamine)

Synonym

Fusidate sodium; Fucidin; Fusidin Sodium fusidate Sodium fusidin; SQ 16360; SQ16360; SQ-16360; ZN 6-NA

IUPAC/Chemical Name

sodium (Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetoxy-3,11-dihydroxy-4,8,10,14-tetramethylhexadecahydro-17H-cyclopenta[a]phenanthren-17-ylidene)-6-methylhept-5-enoate

InChi Key

HJHVQCXHVMGZNC-JCJNLNMISA-M

InChi Code

InChI=1S/C31H48O6.Na/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32;/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36);/q;+1/p-1/b26-20-;/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-;/m0./s1

SMILES Code

C/C(C)=C\CC/C(C([O-])=O)=C1[C@H](C[C@@]2([C@]3(CC[C@]4([C@@H]([C@@H](CC[C@@]4([C@@]3([C@@H](C[C@@]/12[H])O)[H])C)O)C)[H])C)C)OC(C)=O.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 538.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mishriky J, Balassone J, Bashour Z, Kaur S, Raman V, Getachew R, Osman N, Guidone D, Chan V, Little PJ. An Investigation of Sodium Fusidate and Recombinant Cytochrome P450 Enzymes Inhibition In-Vitro. Drug Metab Lett. 2016;10(3):180-186. doi: 10.2174/1872312810666160607015045. PMID: 27280598. 2: Kim DW, Kim KS, Seo YG, Lee BJ, Park YJ, Youn YS, Kim JO, Yong CS, Jin SG, Choi HG. Novel sodium fusidate-loaded film-forming hydrogel with easy application and excellent wound healing. Int J Pharm. 2015 Nov 10;495(1):67-74. doi: 10.1016/j.ijpharm.2015.08.082. Epub 2015 Sep 4. PMID: 26325319. 3: Mulla Z, Edwards M, Nicholson JW. Release of sodium fusidate from glass- ionomer dental cement. J Mater Sci Mater Med. 2010 Jun;21(6):1997-2000. doi: 10.1007/s10856-010-4060-2. Epub 2010 Apr 8. PMID: 20376540. 4: Sodium fusidate. S Afr Med J. 1969 Dec 27;43(51):1537. PMID: 5372049. 5: Eid AM, Istateyeh I, Salhi N, Istateyeh T. Antibacterial Activity of Fusidic Acid and Sodium Fusidate Nanoparticles Incorporated in Pine Oil Nanoemulgel. Int J Nanomedicine. 2019 Dec 2;14:9411-9421. doi: 10.2147/IJN.S229557. PMID: 31819440; PMCID: PMC6898994. 6: Jin SG, Kim KS, Kim DW, Kim DS, Seo YG, Go TG, Youn YS, Kim JO, Yong CS, Choi HG. Development of a novel sodium fusidate-loaded triple polymer hydrogel wound dressing: Mechanical properties and effects on wound repair. Int J Pharm. 2016 Jan 30;497(1-2):114-22. doi: 10.1016/j.ijpharm.2015.12.007. Epub 2015 Dec 4. PMID: 26657270. 7: Carey MC, Small DM. Micellar properties of sodium fusidate, a steroid antibiotic structurally resembling the bile salts. J Lipid Res. 1971 Sep;12(5):604-13. PMID: 5098396. 8: Morley PA, Munot LD. A comparison of sodium fusidate ointment and mupirocin ointment in superficial skin sepsis. Curr Med Res Opin. 1988;11(2):142-8. doi: 10.1185/03007998809110457. PMID: 3146465. 9: Somerville DA, Noble WC, White PM, Seville RH, Savin JA. Sodium fusidate in the treatment of erythrasma. Br J Dermatol. 1971 Nov;85(5):450-3. doi: 10.1111/j.1365-2133.1971.tb14051.x. PMID: 4943603. 10: Sesso R, Parisio K, Dalboni A, Rabelo T, Barbosa D, Cendoroglo M, Pignatari A, Draibe S, Ajzen H. Effect of sodium fusidate and ofloxacin on Staphylococcus aureus colonization and infection in patients on continuous ambulatory peritoneal dialysis. Clin Nephrol. 1994 Jun;41(6):370-6. PMID: 8076441.