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MedKoo Cat#: 412498 | Name: Ceftiolene

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ceftiolene is a third-generation cephalosporin antibiotic.

Chemical Structure

Ceftiolene
CAS#77360-52-2

Theoretical Analysis

MedKoo Cat#: 412498

Name: Ceftiolene

CAS#: 77360-52-2

Chemical Formula: C20H18N8O8S3

Exact Mass: 594.0410

Molecular Weight: 594.59

Elemental Analysis: C, 40.40; H, 3.05; N, 18.85; O, 21.53; S, 16.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Ceftiolene; Ceftiolenum; UNII-28TV2P33KF
IUPAC/Chemical Name
(6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-((E)-2-((5,6-dioxo-4-(2-oxoethyl)-1,4,5,6-tetrahydro-1,2,4-triazin-3-yl)thio)vinyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
InChi Key
WJXAHFZIHLTPFR-JLRJEBFFSA-N
InChi Code
InChI=1S/C20H18N8O8S3/c1-36-26-10(9-7-39-19(21)22-9)13(30)23-11-15(32)28-12(18(34)35)8(6-38-17(11)28)2-5-37-20-25-24-14(31)16(33)27(20)3-4-29/h2,4-5,7,11,17H,3,6H2,1H3,(H2,21,22)(H,23,30)(H,24,31)(H,34,35)/b5-2+,26-10-/t11-,17-/m1/s1
SMILES Code
CO/N=C(c1nc(N)sc1)\C(N[C@H]2[C@H]3SCC(/C=C/SC4=NNC(C(N4CC=O)=O)=O)=C(C(O)=O)N3C2=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 594.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Williamson R, Gutmann L, Kitzis MD, Acar JF. An evaluation of the bacteriolytic and biochemical properties of ceftiolene (42980RP). J Antimicrob Chemother. 1984 Dec;14(6):581-93. doi: 10.1093/jac/14.6.581. PMID: 6394571. 2: Uri JV, Jain TC. Colorimetric detection and spectrophotometric determination of the aminothiazolyl-alkoxyimino beta-lactams. J Antibiot (Tokyo). 1986 May;39(5):669-75. doi: 10.7164/antibiotics.39.669. PMID: 3733516. 3: Rolin O, Zerial A, Bouanchaud DH. Effects comparés de quatre céphalosporines sur l'incorporation d'acide diaminopimélique tritié au cours de la croissance bactérienne [Comparative effects of 4 cephalosporins on the incorporation of tritiated diaminopimelic acid during bacterial growth]. Pathol Biol (Paris). 1984 May;32(5):318-21. French. PMID: 6739141.