Synonym
PM 170, 3-Piperidinemethanol, 1-methyl-, (p-chlorophenoxy)acetate, hydrochloride, EINECS 279-575-7
IUPAC/Chemical Name
3-((2-(4-chlorophenoxy)acetoxy)methyl)-1-methylpiperidin-1-ium chloride
InChi Key
JHJOZTMFSDMYCE-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H20ClNO3.ClH/c1-17-8-2-3-12(9-17)10-20-15(18)11-19-14-6-4-13(16)5-7-14;/h4-7,12H,2-3,8-11H2,1H3;1H
SMILES Code
C[NH+]1CCCC(C1)COC(COc2ccc(Cl)cc2)=O.[Cl-]
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
334.24
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Massicot F, Falcou R, Heymans F, Godfroid JJ, Apfelbaum M. Effects of a new anorectic drug (PM 170) on development of gold thioglucose-induced obesity in mice. Gen Pharmacol. 1987;18(3):249-52. doi: 10.1016/0306-3623(87)90007-3. PMID: 3106136.
2: Sadler AWE, Hogan L, Fraser B, Rendina LM. Cutting edge rare earth radiometals: prospects for cancer theranostics. EJNMMI Radiopharm Chem. 2022 Aug 26;7(1):21. doi: 10.1186/s41181-022-00173-0. PMID: 36018527; PMCID: PMC9418400.
3: Thomas M. Idées actuelles sur le traitement de l'obésité [Current ideas on the treatment of obesity]. Rev Med Interne. 1986 May;7(3):329-33. French. doi: 10.1016/s0248-8663(86)80018-2. PMID: 2429355.
4: Massicot F, Ricquier D, Godfroid JJ, Apfelbaum M. Activation of energy expenditure in the rat by a new non-amphetaminic compound: the (4-chlorophenoxyacetate) N-methyl 3-hydroxymethyl piperidine, hydrochloride (PM 170). Int J Obes. 1985;9(6):451-8. PMID: 3841663.
5: van der Ham M, Albersen M, de Koning TJ, Visser G, Middendorp A, Bosma M, Verhoeven-Duif NM, de Sain-van der Velden MG. Quantification of vitamin B6 vitamers in human cerebrospinal fluid by ultra performance liquid chromatography-tandem mass spectrometry. Anal Chim Acta. 2012 Jan 27;712:108-14. doi: 10.1016/j.aca.2011.11.018. Epub 2011 Nov 18. PMID: 22177072.
6: Massicot F, Arapis G, Falcou R, Apfelbaum M, Godfroid JJ. Activités anti- obésités du chlorhydrate de chloro-4 phénoxyacétate de N-méthyl hydroxyméthyl-3 pipéridine chez des souris traitées par l'aurothioglucose [Anti-obesity activity of 3-hydroxymethyl N-methyl piperidine 4-chlorophenoxyacetate hydrochloride in mice treated with gold thioglucose]. C R Acad Sci III. 1986;303(17):703-8. French. PMID: 3101985.
