IUPAC/Chemical Name
L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-proline, monoacetate
InChi Key
OLIPZUSDWNRQRQ-BPKVXTLESA-N
InChi Code
InChI=1S/C33H57N11O9.C2H4O2/c1-19(45)26(35)29(49)41-20(8-2-3-13-34)30(50)44-17-6-11-23(44)28(48)40-21(9-4-14-38-33(36)37)31(51)43-16-5-10-22(43)27(47)39-18-25(46)42-15-7-12-24(42)32(52)53;1-2(3)4/h19-24,26,45H,2-18,34-35H2,1H3,(H,39,47)(H,40,48)(H,41,49)(H,52,53)(H4,36,37,38);1H3,(H,3,4)/t19-,20+,21+,22+,23+,24+,26+;/m1./s1
SMILES Code
O=C([C@@H]1CCCN1C(CNC([C@@H]2CCCN2C([C@@H](NC([C@@H]3CCCN3C([C@@H](NC([C@H]([C@H](O)C)N)=O)CCCCN)=O)=O)CCCNC(N)=N)=O)=O)=O)O.OC(C)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in PBS (pH 7.2)
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Selank acetate has anxiolytic activity, and is a nootropic, neuropsychotropic, antidepressant, and antistress compound.
In vivo activity:
In this study, Selank significantly activated the learning process in rats with initially poor learning ability, with effects apparent after first dose on training day 1. The maximum optimizing activity of Selank on learning in normal rats was seen on day 3 of repeated administration and training.
Reference: Neurosci Behav Physiol. 2003 Sep;33(7):639-43. https://pubmed.ncbi.nlm.nih.gov/14552529/
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| PBS (pH 7.2) |
15.0 |
19.48 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
811.94
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
1. Pavlov TS, Samonina GE, Bakaeva ZV, Zolotarev YA, Guseva AA. Selank and its metabolites maintain homeostasis in the gastric mucosa. Bull Exp Biol Med. 2007 Jan;143(1):51-3. doi: 10.1007/s10517-007-0014-1. PMID: 18019011.
2. Kozlovskii II, Danchev ND. The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats. Neurosci Behav Physiol. 2003 Sep;33(7):639-43. doi: 10.1023/a:1024444321191. PMID: 14552529.
In vitro protocol:
1. Pavlov TS, Samonina GE, Bakaeva ZV, Zolotarev YA, Guseva AA. Selank and its metabolites maintain homeostasis in the gastric mucosa. Bull Exp Biol Med. 2007 Jan;143(1):51-3. doi: 10.1007/s10517-007-0014-1. PMID: 18019011.
2. Kozlovskii II, Danchev ND. The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats. Neurosci Behav Physiol. 2003 Sep;33(7):639-43. doi: 10.1023/a:1024444321191. PMID: 14552529.
1. Povarov, I.S., Kondratenko, R.V., Derevyagin, V.I., et al. Effect of Selank on spontaneous synaptic activity of rat hippocampal CA1 neurons. Bull. Exp. Biol. Med. 162(5), 640-642 (2017).
2. Kozlovskaya, M.M., Kozlovskii, I.I., Val'dman, E.A., et al. Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress. Neurosci. Behav. Physiol. 33(9), 853-860 (2003).
3. Meshavkin, K.V., Kost, N.V., Sokolov, O.Y., et al. Naloxone-blocked depriming effect of anxiolytic selank on apomorphine-induced behavioral manifestations of hyperfunction of dopamine system. Bull. Exp. Biol. Med. 142(5), 598-600 (2006).
4. Kolomin, T., Morozova, M., Volkova, A., et al. The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action. Mol. Immunol. 58(1), 50-55 (2014).
