Synonym
CLPP-2068; CLPP 2068; CLPP2068
IUPAC/Chemical Name
(R)-3-((2-((4-bromobenzyl)amino)-7-methyl-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)methyl)benzonitrile
InChi Key
ZBPOHFMDQNQRRG-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H22BrN5O/c1-15-9-21-20(14-29(15)13-18-4-2-3-17(10-18)11-25)22(30)28-23(27-21)26-12-16-5-7-19(24)8-6-16/h2-8,10,15H,9,12-14H2,1H3,(H2,26,27,28,30)
SMILES Code
O=C1NC(NCC2=CC=C(Br)C=C2)=NC3=C1CN(CC4=CC(C#N)=CC=C4)[C@@H](C3)C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
464.37
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Sun M, Chen B, Teng D, Zhao H, Liao Y, Zhang C, Huang Q, Ma H, Wang C, Lin X, Yu P, Yuan Q, Yu J, Xu L, Hu X, Ye F, Diao X, Zheng M, Yin W, Zhou Y, Li J, Wang M. Harnessing the Magic Methyl Effect: Discovery of CLPP-2068 as a Novel HsClpP Activator for the Treatment of Diffuse Large B-Cell Lymphoma. J Med Chem. 2025 Feb 11. doi: 10.1021/acs.jmedchem.4c02016. Epub ahead of print. PMID: 39935096.
