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MedKoo Cat#: 462209 | Name: PM 226

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PM 226 is a potent and selective CB2 receptor agonist that is BBB permeable and neuroprotective.

Chemical Structure

PM 226
PM 226
CAS#1949726-13-9

Theoretical Analysis

MedKoo Cat#: 462209

Name: PM 226

CAS#: 1949726-13-9

Chemical Formula: C22H31NO3

Exact Mass: 357.2304

Molecular Weight: 357.49

Elemental Analysis: C, 73.92; H, 8.74; N, 3.92; O, 13.43

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PM 226
IUPAC/Chemical Name
9-methoxy-4,4-dimethyl-7-(2-methyloctan-2-yl)-4H-chromeno[3,4-d]isoxazole
InChi Key
VFWIRWAAMNBBFG-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H31NO3/c1-7-8-9-10-11-21(2,3)15-12-17(24-6)19-18(13-15)25-22(4,5)16-14-23-26-20(16)19/h12-14H,7-11H2,1-6H3
SMILES Code
COC1=C2C(OC(C)(C)C3=C2ON=C3)=CC(C(C)(C)CCCCCC)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 357.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Navarro G, Morales P, Rodríguez-Cueto C, Fernández-Ruiz J, Jagerovic N, Franco R. Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders. Front Neurosci. 2016;10:406. Published 2016 Sep 13. doi:10.3389/fnins.2016.00406 2: Morales P, Gómez-Cañas M, Navarro G, et al. Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis. J Med Chem. 2016;59(14):6753-6771. doi:10.1021/acs.jmedchem.6b00397 3: Gómez-Cañas M, Morales P, García-Toscano L, et al. Biological characterization of PM226, a chromenoisoxazole, as a selective CB2 receptor agonist with neuroprotective profile. Pharmacol Res. 2016;110:205-215. doi:10.1016/j.phrs.2016.03.021