Vancomycin CDP-1 | CAS# 55598-85-1 | antibiotic

MedKoo Cat#: 412478 | Name: Vancomycin CDP-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Vancomycin CDP-1 is an antibiotic

Chemical Structure

Vancomycin CDP-1

CAS#55598-85-1

Theoretical Analysis

MedKoo Cat#: 412478

Name: Vancomycin CDP-1

CAS#: 55598-85-1

Chemical Formula: C66H74Cl2N8O25

Exact Mass: 1448.4142

Molecular Weight: 1450.25

Elemental Analysis: C, 54.66; H, 5.14; Cl, 4.89; N, 7.73; O, 27.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Vancomycin CDP-1; CDPI; CDP I; CDP-I

IUPAC/Chemical Name

23H-9,12:19,22-Dietheno-24,37-(iminomethano)-14,17:32,36-dimetheno-17H-(1,6,10)oxadiazacycloheptadecino(4,5-m)(10,2,16)benzoxadiazacyclotetracosine-4,27-dicarboxylic acid, 45-((2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl)-beta-D-glucopyranosyl)oxy)-11,20-dichloro-1,2,3,4,5,6,7,8,24,25,26,27,37,38,39,39a-hexadecahydro-8,23,29,31,33-pentahydroxy-7-((4-methyl-2-(methylamino)-1-oxopentyl)amino)-2,6,25,39,40-pentaoxo

InChi Key

OGMARHJAPWBNFA-UHFFFAOYSA-N

InChi Code

InChI=1S/C66H74Cl2N8O25/c1-23(2)12-34(70-5)58(87)75-49-51(82)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(85)53(84)42(22-77)99-65)100-44-21-66(4,69)57(86)24(3)96-44)98-39-11-8-27(15-33(39)68)52(83)50-62(91)74-48(64(94)95)31-18-29(78)19-37(80)45(31)30-13-25(6-9-36(30)79)46(59(88)76-50)73-60(89)47(28)72-43(81)20-35(63(92)93)71-61(49)90/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,70,77-80,82-86H,12,20-22,69H2,1-5H3,(H,71,90)(H,72,81)(H,73,89)(H,74,91)(H,75,87)(H,76,88)(H,92,93)(H,94,95)

SMILES Code

CNC(C(NC1C(c2cc(Cl)c(Oc3c(OC4OC(C(C(C4OC5CC(N)(C(C(O5)C)O)C)O)O)CO)c(Oc6c(Cl)cc(C(C7NC(C(c8cc(c9c(C(C(O)=O)NC7=O)cc(O)cc9O)c(O)cc8)NC(C%10NC(CC(C(O)=O)NC1=O)=O)=O)=O)O)cc6)cc%10c3)cc2)O)=O)CC(C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,450.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Backes DW, Aboleneen HI, Simpson JA. Quantitation of vancomycin and its crystalline degradation product (CDP-1) in human serum by high performance liquid chromatography. J Pharm Biomed Anal. 1998 Apr;16(8):1281-7. doi: 10.1016/s0731-7085(97)00140-4. PMID: 9777601. 2: Anne L, Hu M, Chan K, Colin L, Gottwald K. Potential problem with fluorescence polarization immunoassay cross-reactivity to vancomycin degradation product CDP-1: its detection in sera of renally impaired patients. Ther Drug Monit. 1989 Sep;11(5):585-91. PMID: 2683253. 3: Melichercik P, Klapkova E, Landor I, Judl T, Sibek M, Jahoda D. The effect of Vancomycin degradation products in the topical treatment of osteomyelitis. Bratisl Lek Listy. 2014;115(12):796-9. doi: 10.4149/bll_2014_154. PMID: 25520231. 4: Klapkova E, Nescakova M, Melichercik P, Jahoda D, Dunovska K, Cepova J, Prusa R. Vancomycin and its crystalline degradation products released from bone grafts and different types of bone cement. Folia Microbiol (Praha). 2020 Jun;65(3):475-482. doi: 10.1007/s12223-019-00752-w. Epub 2019 Oct 25. PMID: 31654320. 5: Somerville AL, Wright DH, Rotschafer JC. Implications of vancomycin degradation products on therapeutic drug monitoring in patients with end-stage renal disease. Pharmacotherapy. 1999 Jun;19(6):702-7. doi: 10.1592/phco.19.9.702.31548. PMID: 10391415. 6: Yan J, Guo Z, Ding J, Shen A, Wang J, Jin G, Liang X. [Analysis of vancomycin and its related impurities by hydrophilic interaction liquid chromatography]. Se Pu. 2015 Sep;33(9):951-6. Chinese. doi: 10.3724/sp.j.1123.2015.05032. PMID: 26753283. 7: Ng SM, Wu X, Khyasudeen MF, Nowakowski PJ, Tan HS, Xing B, Yeow EKL. Vancomycin Determination by Disrupting Electron-Transfer in a Fluorescence Turn- On Squaraine-Anthraquinone Triad. ACS Sens. 2018 Jun 22;3(6):1156-1163. doi: 10.1021/acssensors.8b00188. Epub 2018 Jun 7. PMID: 29792330. 8: Lewis PO, Kirk LM, Brown SD. Comparison of three generic vancomycin products using liquid chromatography-mass spectrometry and an online tool. Am J Health Syst Pharm. 2014 Jun 15;71(12):1029-38. doi: 10.2146/ajhp130516. PMID: 24865760. 9: Morishige H, Shuto H, Ieiri I, Otsubo K, Oishi R. Instability of standard calibrators may be involved in overestimating vancomycin concentrations determined by fluorescence polarization immunoassay. Ther Drug Monit. 1996 Feb;18(1):80-5. doi: 10.1097/00007691-199602000-00013. PMID: 8848826. 10: Sym D, Smith C, Meenan G, Lehrer M. Fluorescence polarization immunoassay: can it result in an overestimation of vancomycin in patients not suffering from renal failure? Ther Drug Monit. 2001 Aug;23(4):441-4. doi: 10.1097/00007691-200108000-00020. PMID: 11477330.