ZYDPLA1 | CAS#1263402-76-1 | DPP-4 inhibitor

MedKoo Cat#: 466152 | Name: ZYDPLA1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZYDPLA1 is a novel next generation orally active DPP-4 inhibitor to treat Type 2 Diabetes.

Chemical Structure

ZYDPLA1

CAS#1263402-76-1

Theoretical Analysis

MedKoo Cat#: 466152

Name: ZYDPLA1

CAS#: 1263402-76-1

Chemical Formula: C24H21N5O5S

Exact Mass: 491.1263

Molecular Weight: 491.52

Elemental Analysis: C, 58.65; H, 4.31; N, 14.25; O, 16.27; S, 6.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ZYDPLA1; ZYDPLA 1; ZYDPLA-1;

IUPAC/Chemical Name

(S)-3-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)-5-((1-methyl-2-oxopyrrolidin-3-yl)oxy)-N-(thiazol-2-yl)benzamide

InChi Key

AOZKMKQCNOIYGR-FQEVSTJZSA-N

InChi Code

InChI=1S/C24H21N5O5S/c1-14-27-28-22(32-14)15-3-5-17(6-4-15)33-18-11-16(21(30)26-24-25-8-10-35-24)12-19(13-18)34-20-7-9-29(2)23(20)31/h3-6,8,10-13,20H,7,9H2,1-2H3,(H,25,26,30)/t20-/m0/s1

SMILES Code

O=C(NC1=NC=CS1)C2=CC(O[C@@H]3C(N(C)CC3)=O)=CC(OC4=CC=C(C5=NN=C(C)O5)C=C4)=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 491.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Giri P, Patel N, Patel B, Patel H, Bahekar R, Srinivas NR, Patel PR, Desai R. Sensitive and specific LC-ESI-MS/MS method for determination of ZYDPLA1, a novel long-acting dipeptidyl peptidase 4 inhibitor in rat plasma: An application for toxicokinetic study in rats. Biomed Chromatogr. 2017 Nov;31(11). doi: 10.1002/bmc.3984. Epub 2017 May 29. PMID: 28370279. 2: Patel H, Joharapurkar AA, Bahekar R, Patel P, Kshirsagar SG, Modi N, Ghoghari A, Patel VJ, Jain MR, Srinivas NR, Patel PR, Desai RC. Is the Inhibition of Dipeptidyl Peptidase-4 (DDP-4) Enzyme Route Dependent and/or Driven by High Peak Concentration?- Seeking Answers with ZYDPLA1, a Novel Long Acting DPP-4 Inhibitor, in a Rodent Model. Drug Res (Stuttg). 2017 Apr;67(4):223-227. doi: 10.1055/s-0042-122776. Epub 2017 Feb 3. PMID: 28158894. 3: Jain MR, Joharapurkar AA, Bahekar RH, Patel H, Jadav P, Kshirsagar SG, Patel VJ, Patel KN, Ramanathan VK, Patel PR, Desai RC. Pharmacological characterization of ZYDPLA1, a novel long-acting dipeptidyl peptidase-4 inhibitor. J Diabetes. 2015 Sep;7(5):708-17. doi: 10.1111/1753-0407.12233. Epub 2014 Dec 17. PMID: 25327540.