BAI2 | CAS#335166-36-4 | BAX inhibitor

MedKoo Cat#: 565687 | Name: BAI2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BAI2 is a BAX inhibitor. BAI2 bind directly to a previously unrecognized pocket and allosterically inhibits BAX activation. BAI2 binding around the hydrophobic helix α5 using hydrophobic and hydrogen bonding interactions stabilizes key areas of the hydrophobic core. BAI2 inhibit conformational events in BAX activation that prevent BAX mitochondrial translocation and oligomerization.

Chemical Structure

BAI2

CAS#335166-36-4

Theoretical Analysis

MedKoo Cat#: 565687

Name: BAI2

CAS#: 335166-36-4

Chemical Formula: C19H20Br2FN3

Exact Mass: 467.0008

Molecular Weight: 469.20

Elemental Analysis: C, 48.64; H, 4.30; Br, 34.06; F, 4.05; N, 8.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

BAI2; BAI 2; BAI-2;

IUPAC/Chemical Name

3,6-Dibromo-9-(2-fluoro-3-(piperazin-1-yl)propyl)-9H-carbazole

InChi Key

BSTYITXHUQTYBA-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H20Br2FN3/c20-13-1-3-18-16(9-13)17-10-14(21)2-4-19(17)25(18)12-15(22)11-24-7-5-23-6-8-24/h1-4,9-10,15,23H,5-8,11-12H2

SMILES Code

FC(CN1CCNCC1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

BAX is a critical effector of the mitochondrial cell death pathway in response to a diverse range of stimuli in physiological and disease contexts. Upon binding by BH3-only proteins, cytosolic BAX undergoes conformational activation and translocation, resulting in mitochondrial outer-membrane permeabilization. Efforts to rationally target BAX and develop inhibitors have been elusive, despite the clear therapeutic potential of inhibiting BAX-mediated cell death in a host of diseases.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 469.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Garner TP, Amgalan D, Reyna DE, Li S, Kitsis RN, Gavathiotis E. Small-molecule allosteric inhibitors of BAX. Nat Chem Biol. 2019 Apr;15(4):322-330. doi: 10.1038/s41589-018-0223-0. Epub 2019 Feb 4. PMID: 30718816; PMCID: PMC6430685.