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MedKoo Cat#: 412475 | Name: CDD-0102 hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CDD-0102 hydrochloride is the salt form of CDD-0102 (free base), a small molecule that selectively activates M1 muscarinic receptors, exhibits a low side effect profile at doses that enhance memory function in rodents, and displays neuroprotective effects in cell culture.

Chemical Structure

CDD-0102 hydrochloride
CAS#1196130-86-5 (HCl)

Theoretical Analysis

MedKoo Cat#: 412475

Name: CDD-0102 hydrochloride

CAS#: 1196130-86-5 (HCl)

Chemical Formula: C8H13ClN4O

Exact Mass: 216.0778

Molecular Weight: 216.67

Elemental Analysis: C, 44.35; H, 6.05; Cl, 16.36; N, 25.86; O, 7.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
CAS# 146422-58-4 (free base); 1196130-86-5 (HCl)
Synonym
CDD-0102 hydrochloride; UNII-6P87MRR8OA
IUPAC/Chemical Name
3-ethyl-5-(1,4,5,6-tetrahydropyrimidin-5-yl)-1,2,4-oxadiazole hydrochloride
InChi Key
FVWAMONNJGNNHY-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H12N4O.ClH/c1-2-7-11-8(13-12-7)6-3-9-5-10-4-6;/h5-6H,2-4H2,1H3,(H,9,10);1H
SMILES Code
CCc1nc(C2CNC=NC2)on1.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 216.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bachmann K, Telang U, Byers J, Hoss W. The processing of the selective M1 agonist CDD-0102-J by human hepatic drug metabolizing enzymes. Am J Ther. 2005 Jul-Aug;12(4):300-5. doi: 10.1097/01.pgp.0000145356.05787.19. PMID: 16041192. 2: Messer WS Jr. The utility of muscarinic agonists in the treatment of Alzheimer's disease. J Mol Neurosci. 2002 Aug-Oct;19(1-2):187-93. doi: 10.1007/s12031-002-0031-5. PMID: 12212779. 3: Messer WS Jr, Rajeswaran WG, Cao Y, Zhang HJ, el-Assadi AA, Dockery C, Liske J, O'Brien J, Williams FE, Huang XP, Wroblewski ME, Nagy PI, Peseckis SM. Design and development of selective muscarinic agonists for the treatment of Alzheimer's disease: characterization of tetrahydropyrimidine derivatives and development of new approaches for improved affinity and selectivity for M1 receptors. Pharm Acta Helv. 2000 Mar;74(2-3):135-40. doi: 10.1016/s0031-6865(99)00026-6. PMID: 10812950.

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