Synonym
NLA 1; NLA1; NLA-1
IUPAC/Chemical Name
9-Acridinamine, N-(3-(2-nitro-1H-imidazol-1-yl)propyl)-, monohydrochloride
InChi Key
BYQPDMUOXXCZOV-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H17N5O2.ClH/c25-24(26)19-21-11-13-23(19)12-5-10-20-18-14-6-1-3-8-16(14)22-17-9-4-2-7-15(17)18;/h1-4,6-9,11,13H,5,10,12H2,(H,20,22);1H
SMILES Code
O=[N+](C1=NC=CN1CCCNC2=C(C=CC=C3)C3=NC4=CC=CC=C42)[O-].[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
383.84
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Papadopoulou MV, Rosenzweig HS, Doddi M, Bloomer WD. 9-[3-(2-Nitro-1-imidazolyl)propylamino]-1,2,3,4-tetrahydroacridine hydrochloride. A novel DNA-affinic hypoxic cell cytotoxin and radiosensitizer. Comparison with NLA-1. Oncol Res. 1994;6(9):439-48. PubMed PMID: 7703530.
2: Papadopoulou MV, Epperly MW, Shields DS, Bloomer WD. Radiosensitization and hypoxic cell toxicity of NLA-1 and NLA-2, two new bioreductive compounds. Jpn J Cancer Res. 1992 Apr;83(4):410-4. PubMed PMID: 1506276; PubMed Central PMCID: PMC5918828.
3: Denny WA, Roberts PB, Anderson RF, Brown JM, Phil D, Wilson WR. NLA-1: a 2-nitroimidazole radiosensitizer targeted to DNA by intercalation. Int J Radiat Oncol Biol Phys. 1992;22(3):553-6. PubMed PMID: 1735695.
4: Papadopoulou MV, Mainwaring A, Bloomer WD. Potentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea's toxicity in vitro by two new bioreductive agents. Jpn J Cancer Res. 1992 Aug;83(8):907-13. PubMed PMID: 1399828; PubMed Central PMCID: PMC5918954.
