Synonym
Prolintane hydrochloride; H246; H-246; H 246
IUPAC/Chemical Name
1-(1-phenylpentan-2-yl)pyrrolidine hydrochloride
InChi Key
FKOFBBOQSMUYHD-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H23N.ClH/c1-2-8-15(16-11-6-7-12-16)13-14-9-4-3-5-10-14;/h3-5,9-10,15H,2,6-8,11-13H2,1H3;1H
SMILES Code
CCCC(N1CCCC1)Cc2ccccc2.Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
253.81
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kyle PB, Daley WP. Domestic abuse of the European rave drug prolintane. J Anal Toxicol. 2007 Sep;31(7):415-8. doi: 10.1093/jat/31.7.415. PMID: 17725890.
2: Martínez-Mir I, Catalán C, Palop V. Prolintane: a "masked" amphetamine. Ann Pharmacother. 1997 Feb;31(2):256. doi: 10.1177/106002809703100228. PMID: 9034438.
3: Gaulier JM, Canal M, Pradeille JL, Marquet P, Lachâtre G. Nouvelles drogues de « rave-parties » : ketamine et prolintane. Acta Clin Belg. 2002;57 Suppl 1:41-6. doi: 10.1179/acb.2002.076. PMID: 24862524.
4: Fuller RW, Snoddy HD. Effects of prolintane on 3,4-dihydroxyphenylacetic acid concentration in rat brain after spiperone treatment. Pharmacol Biochem Behav. 1979 Apr;10(4):561-3. doi: 10.1016/0091-3057(79)90233-8. PMID: 572552.
5: Payá B, Guisado JA, Vaz FJ, Crespo-Facorro B. Visual hallucinations induced by the combination of prolintane and diphenhydramine. Pharmacopsychiatry. 2002 Jan;35(1):24-5. doi: 10.1055/s-2002-19829. PMID: 11819155.
6: Souders CL 2nd, Davis RH, Qing H, Liang X, Febo M, Martyniuk CJ. The psychoactive cathinone derivative pyrovalerone alters locomotor activity and decreases dopamine receptor expression in zebrafish (Danio rerio). Brain Behav. 2019 Nov;9(11):e01420. doi: 10.1002/brb3.1420. Epub 2019 Oct 18. PMID: 31625691; PMCID: PMC6851804.
7: Rücker G, Neugebauer M, Zhong D. Synthese einiger Metaboliten und der Enantiomeren des Prolintans [Synthesis of metabolites and enantiomers of prolintane]. Arch Pharm (Weinheim). 1992 Jan;325(1):47-52. German. doi: 10.1002/ardp.19923250111. PMID: 1605711.
8: Gaulier JM, Canal M, Pradeille JL, Marquet P, Lachâtre G. Nouvelles drogues de "rave-parties": Kétamine et Prolintane [New drugs at "rave parties": ketamine and prolintane]. Acta Clin Belg. 2002;57 Suppl 1:41-6. French. PMID: 11974443.
9: Nicholson AN, Stone BM, Jones MM. Wakefullness and reduced rapid eye movement sleep: studies with prolintane and pemoline. Br J Clin Pharmacol. 1980 Nov;10(5):465-72. doi: 10.1111/j.1365-2125.1980.tb01790.x. PMID: 7437258; PMCID: PMC1430138.
10: Espartero AG, Pérez JA, Zapardiel A, Bermejo E, Hernández L. Direct determination of prolintane and its metabolite oxoprolintane in human urine by capillary zone electrophoresis and beta-cyclodextrin-modified micellar electrokinetic chromatography. J Chromatogr A. 1997 Aug 22;778(1-2):355-61. doi: 10.1016/s0021-9673(97)00478-0. PMID: 9299746.
