MedKoo Cat#: 463360 | Name: FAPL-S0456

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FAPL-S0456 is a novel FAP-targeted NIR dye conjugate. FAPL-S0456 has similar fluorescence parameters as (CR)-S0456 since the fluorescent fluorochrome (S0456) is the same for both molecules but is targeted to the fibroblast activation protein transmembrane receptor instead of SMVT. Mice treated with omipalisib but infused with FAPL-S0456 demonstrated strong fluorescence emission detection by nCLE.

Chemical Structure

FAPL-S0456
FAPL-S0456
CAS#2415941-99-8

Theoretical Analysis

MedKoo Cat#: 463360

Name: FAPL-S0456

CAS#: 2415941-99-8

Chemical Formula: C75H88F2N10O22S5

Exact Mass: 1678.4646

Molecular Weight: 1679.87

Elemental Analysis: C, 53.62; H, 5.28; F, 2.26; N, 8.34; O, 20.95; S, 9.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
2230625-79-1 2415941-99-8
Synonym
FAPL-S0456; FAPLS0456; FAPL S0456;
IUPAC/Chemical Name
2-((E)-2-((E)-2-(4-(3-((2-(3-((2-carboxy-2-(4-(((4-(((S)-1-((S)-2-cyano-4,4-difluoropyrrolidin-1-yl)-1-oxopropan-2-yl)carbamoyl)pyridin-2-yl)methyl)amino)-4-oxobutanamido)ethyl)thio)-2,5-dioxopyrrolidin-1-yl)ethyl)amino)-3-oxopropyl)phenoxy)-3-(2-((E)-3,3-dimethyl-5-sulfo-1-(4-sulfobutyl)indolin-2-ylidene)ethylidene)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfobutyl)-3H-indol-1-ium-5-sulfonate
InChi Key
AXPOYZRNGOZGAA-RIPVVRRZSA-N
InChi Code
InChI=1S/C75H88F2N10O22S5/c1-46(70(93)87-45-75(76,77)41-52(87)42-78)82-69(92)50-29-30-79-51(37-50)43-81-65(89)27-28-66(90)83-58(72(95)96)44-110-61-40-67(91)86(71(61)94)34-31-80-64(88)26-15-47-13-18-53(19-14-47)109-68-48(16-24-62-73(2,3)56-38-54(113(103,104)105)20-22-59(56)84(62)32-6-8-35-111(97,98)99)11-10-12-49(68)17-25-63-74(4,5)57-39-55(114(106,107)108)21-23-60(57)85(63)33-7-9-36-112(100,101)102/h13-14,16-25,29-30,37-39,46,52,58,61H,6-12,15,26-28,31-36,40-41,43-45H2,1-5H3,(H8-,80,81,82,83,88,89,90,92,95,96,97,98,99,100,101,102,103,104,105,106,107,108)/t46-,52-,58?,61?/m0/s1
SMILES Code
O=S(C1=CC2=C([N+](CCCCS(=O)(O)=O)=C(/C=C/C3=C(OC4=CC=C(CCC(NCCN5C(C(SCC(C(O)=O)NC(CCC(NCC6=NC=CC(C(N[C@@H](C)C(N7[C@H](C#N)CC(F)(F)C7)=O)=O)=C6)=O)=O)CC5=O)=O)=O)C=C4)/C(CCC3)=C/C=C8N(CCCCS(=O)(O)=O)C9=C(C=C(S(=O)(O)=O)C=C9)C/8(C)C)C2(C)C)C=C1)([O-])=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,679.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL