Synonym
Carsatrin; UNII-2E3S34L69I
IUPAC/Chemical Name
1-Piperazineethanol, 4-(bis(4-fluorophenyl)methyl)-alpha-((1H-purin-6-ylthio)methyl)-
InChi Key
JOMBZLFCXNSKEQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H26F2N6OS/c26-19-5-1-17(2-6-19)23(18-3-7-20(27)8-4-18)33-11-9-32(10-12-33)13-21(34)14-35-25-22-24(29-15-28-22)30-16-31-25/h1-8,15-16,21,23,34H,9-14H2,(H,28,29,30,31)
SMILES Code
OC(CSC1=C2N=CN=C2N=CN1)CN3CCN(C(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
496.58
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Press JB, Falotico R, Hajos ZG, Sawyers RA, Kanojia RM, Williams L, Haertlein B, Kauffman JA, Lakas-Weiss C, Salata JJ. Synthesis and SAR of 6-substituted purine derivatives as novel selective positive inotropes. J Med Chem. 1992 Nov 27;35(24):4509-15. doi: 10.1021/jm00102a001. PMID: 1335073.
2: Tsushima RG, Kelly JE, Salata JJ, Liberty KN, Wasserstrom JA. Modification of cardiac Na(+) current by RWJ 24517 and its enantiomers in guinea pig ventricular myocytes. J Pharmacol Exp Ther. 1999 Nov;291(2):845-55. PMID: 10525108.
3: Krafte DS, Davison K, Dugrenier N, Estep K, Josef K, Barchi RL, Kallen RG, Silver PJ, Ezrin AM. Pharmacological modulation of human cardiac Na+ channels. Eur J Pharmacol. 1994 Feb 15;266(3):245-54. doi: 10.1016/0922-4106(94)90133-3. PMID: 8174607.
4: Kawamura A, Wahler GM, Solaro RJ. RWJ-24517, a positive inotropic agent, has novel effects on action potentials in guinea pig myocardium. J Cardiovasc Pharmacol. 1993 Oct;22(4):519-25. doi: 10.1097/00005344-199310000-00003. PMID: 7505352.