MedKoo Cat#: 463356 | Name: Dibenzepin hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dibenzepin hydrochloride, sold under the brand name Noveril among others, is a tricyclic antidepressant (TCA) used widely throughout Europe for the treatment of depression. It has similar efficacy and effects relative to other TCAs like imipramine but with fewer side effects.

Chemical Structure

Dibenzepin hydrochloride
CAS#315-80-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 463356

Name: Dibenzepin hydrochloride

CAS#: 315-80-0 (HCl)

Chemical Formula: C18H22ClN3O

Exact Mass: 331.1451

Molecular Weight: 331.84

Elemental Analysis: C, 65.15; H, 6.68; Cl, 10.68; N, 12.66; O, 4.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Dibenzepin hydrochloride; Dibenzepin HCl; Dibenzepine monohydrochloride; Ecatril; NSC 169412; NSC169412; NSC-169412; Neodalit; Noveril; Sedatiplex;
IUPAC/Chemical Name
10-(2-(dimethylamino)ethyl)-5-methyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one hydrochloride
InChi Key
RJPZIQRLRMWPRF-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H21N3O.ClH/c1-19(2)12-13-21-17-11-7-6-10-16(17)20(3)15-9-5-4-8-14(15)18(21)22;/h4-11H,12-13H2,1-3H3;1H
SMILES Code
CN(CCN1C(c2c(N(c3c1cccc3)C)cccc2)=O)C.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 331.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zahradník I, Minarovic I, Zahradníková A. Inhibition of the cardiac L-type calcium channel current by antidepressant drugs. J Pharmacol Exp Ther. 2008 Mar;324(3):977-84. doi: 10.1124/jpet.107.132456. Epub 2007 Nov 29. PMID: 18048694. 2: Gutteck U, Rentsch KM. Therapeutic drug monitoring of 13 antidepressant and five neuroleptic drugs in serum with liquid chromatography-electrospray ionization mass spectrometry. Clin Chem Lab Med. 2003 Dec;41(12):1571-9. doi: 10.1515/CCLM.2003.240. PMID: 14708881. 3: Beresewicz M, Bidzińska E, Koszewska I, Puzyński S. Wyniki stosowania trójpierścieniowych leków przeciwdepresyjnych w terapii depresji endogennej (analiza porównawcza 7 leków) [Results of using tricyclic antidepressive drugs in the treatment of endogenous depression (comparative analysis of 7 drugs)]. Psychiatr Pol. 1991 May-Aug;25(3-4):13-8. Polish. PMID: 1687987. 4: Velasco-Martín A, Garcia JL, Dueñas A. Effects of several neuroleptics, antidepressants and monoamine uptake blockers on ATPase activity and related oxygen uptake in rat brain in vitro. Methods Find Exp Clin Pharmacol. 1989 Dec;11(12):737-41. PMID: 2576298. 5: Cassidy S, Henry J. Fatal toxicity of antidepressant drugs in overdose. Br Med J (Clin Res Ed). 1987 Oct 24;295(6605):1021-4. doi: 10.1136/bmj.295.6605.1021. Erratum in: Br Med J (Clin Res Ed) 1987 Nov 28;295(6610):1382. PMID: 3690249; PMCID: PMC1248068. 6: Miyakawa A, Nishimura M, Watanabe Y. Electrophysiologic actions of dibenzepin, a tricyclic antidepressant, on canine Purkinje fibers. J Cardiovasc Pharmacol. 1986 Jul-Aug;8(4):811-7. doi: 10.1097/00005344-198709010-00024. PMID: 2427823.