Synonym
Carpipramine dihydrochloride; Carpipramine; PZ1511; PZ-1511; PZ 1511; Carbadipimidine; Carpipramina; Carpipraminum
IUPAC/Chemical Name
(1,4'-Bipiperidine)-4'-carboxamide, 1'-(3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)-, dihydrochloride, monohydrate
InChi Key
DQZZUZZSEFHBSL-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H38N4O.2ClH.H2O/c29-27(33)28(31-18-6-1-7-19-31)15-21-30(22-16-28)17-8-20-32-25-11-4-2-9-23(25)13-14-24-10-3-5-12-26(24)32;;;/h2-5,9-12H,1,6-8,13-22H2,(H2,29,33);2*1H;1H2
SMILES Code
O=C(C1(N2CCCCC2)CCN(CCCN3C4=CC=CC=C4CCC5=CC=CC=C53)CC1)N.[H]Cl.[H]Cl.[H]O[H]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
537.57
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: des Lauriers A, Clery-Melin P, Allilaire JF, Baruch P, Ammar S, Vilamot B. A propos de la carpipramine [Carpipramine]. Encephale. 1990 Jan-Feb;16(1):53. French. PMID: 2328685.
2: Kishi T, Matsunaga S, Matsuda Y, Iwata N. Iminodibenzyl class antipsychotics for schizophrenia: a systematic review and meta-analysis of carpipramine, clocapramine, and mosapramine. Neuropsychiatr Dis Treat. 2014 Dec 10;10:2339-51. doi: 10.2147/NDT.S73464. PMID: 25525363; PMCID: PMC4266422.
3: Woggon B, Angst J. Das Wirkungsprofil von Carpipramin. Ergebnisse einer offenen Prüfung und einer Doppelblindprüfung gegen Doxepin [Activity profile of carpipramine. Results of an open trial and a double-blind trial versus doxepin]. Arzneimittelforschung. 1976;26(12):2226-30. German. PMID: 14652.
4: Sechter D, Loo H. Les antagonistes 5HT2* et la carpipramine [5 HT2 antagonists and carpipramine]. Rev Prat. 1990 Nov 1;40(25):2363-5. French. PMID: 2124722.
5: Deniker P, Lôo H, Zarifian E, Verdeaux G, Garreau G. Un nouveau médicament psychotrope: la carpipramine, composé de transition entre deux classes thérapeutiques [A new psychotropic drug: carpipramine, intermediate compound between 2 therapeutic classes]. Encephale. 1977;3(2):133-48. French. PMID: 19231.
6: Fontan M, Goudemand M, Roeland P, Gamblin P. La carpipramine comme traitement de l'inhibition [Carpipramine as treatment of inhibition]. Lille Med. 1979 Feb;24(2):151-5. French. PMID: 372716.
7: Peyrouzet JM, Périer M. La carpipramine dans les névroses [Carpipramine in neuroses]. Encephale. 1978;4(5 Suppl):577-85. French. PMID: 380971.
8: Athen D, Bente D, Bikadorow V, Feder J, Müller-Oerlinghausen B. Das klinische Wirkungsspektrum mittlerer und hoher Dosen von Carpipramin [Clinical effects of moderate and high doses of carpipramine (author's transl)]. Pharmakopsychiatr Neuropsychopharmakol. 1975 Sep;8(5):269-309. German. PMID: 1233521.
9: Dagonneau H, Fonlupt P, Pacheco H. Effets, chez le Rat, de la métapramine et de la carpipramine sur le recaptage des catécholamines et de la sérotonine; relation avec la fixation de l'3H-imipramine [Effects, in rats, of metapramine and carpipramine on the uptake of catecholamines and serotonin; relationship with 3H-imipramine binding]. C R Seances Soc Biol Fil. 1986;180(1):43-8. French. PMID: 3017518.
10: von Stralendorff B, Ackenheil M, Zimmermann J. Akute und chronische Wirkung von Carpipramin, Clozapin, Haloperidol und Sulpirid auf den Stoffwechsel biogener Amine im Rattengehirn [Acute and chronic effects of carpipramine, clozapine, haloperidol and sulpiride on the metabolism of biogenic amines in the rat brain (author's transl)]. Arzneimittelforschung. 1976;26(6):1096-8. German. PMID: 9108.
