MedKoo Cat#: 412379 | Name: Carnitine orotate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Carnitine orotate is a biochemical

Chemical Structure

Carnitine orotate
Carnitine orotate
CAS#32543-38-7

Theoretical Analysis

MedKoo Cat#: 412379

Name: Carnitine orotate

CAS#: 32543-38-7

Chemical Formula: C12H19N3O7

Exact Mass: 317.1223

Molecular Weight: 317.29

Elemental Analysis: C, 45.42; H, 6.04; N, 13.24; O, 35.30

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Synonym
Carnitine orotate; UNII83EYV27FW2; UNII 83EYV27FW2; UNII-83EYV27FW2
IUPAC/Chemical Name
1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylate (1:1)
InChi Key
MBULCFMSBDQQQT-UHFFFAOYSA-N
InChi Code
InChI=1S/C7H15NO3.C5H4N2O4/c1-8(2,3)5-6(9)4-7(10)11;8-3-1-2(4(9)10)6-5(11)7-3/h6,9H,4-5H2,1-3H3;1H,(H,9,10)(H2,6,7,8,11)
SMILES Code
C[N+](C)(C)CC(O)CC(O)=O.O=C(C(NC1=O)=CC(N1)=O)[O-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 317.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhu HS, Wang YY, Lin MW, Du JX, Hang LQ, Chen Y, Wang LF. Carnitine and carnitine orotate affect the expression of the prolactin-releasing peptide gene. Genet Mol Res. 2011 Dec 6;10(4):3013-9. doi: 10.4238/2011.December.6.1. PMID: 22180034. 2: An JH, Youn W, Kiyonga AN, Lim C, Park M, Suh YG, Ryu HC, Kim JS, Park CW, Jung K. Kinetics of the Solution-Mediated Polymorphic Transformation of the Novel l-Carnitine Orotate Polymorph, Form-II. Pharmaceutics. 2018 Oct 1;10(4):171. doi: 10.3390/pharmaceutics10040171. PMID: 30275413; PMCID: PMC6321437. 3: Bae JC, Lee WY, Yoon KH, Park JY, Son HS, Han KA, Lee KW, Woo JT, Ju YC, Lee WJ, Cho YY, Lee MK. Improvement of Nonalcoholic Fatty Liver Disease With Carnitine-Orotate Complex in Type 2 Diabetes (CORONA): A Randomized Controlled Trial. Diabetes Care. 2015 Jul;38(7):1245-52. doi: 10.2337/dc14-2852. Epub 2015 Apr 15. PMID: 25877813. 4: Hong ES, Kim EK, Kang SM, Khang AR, Choi SH, Park KS, Jang HC, Lim S. Effect of carnitine-orotate complex on glucose metabolism and fatty liver: a double- blind, placebo-controlled study. J Gastroenterol Hepatol. 2014;29(7):1449-57. doi: 10.1111/jgh.12536. PMID: 24611967. 5: Nunes V, Niinikoski H. Lysinuric Protein Intolerance. 2006 Dec 21 [updated 2018 Apr 12]. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2020. PMID: 20301535. 6: Chen Q, Liu M, Yu H, Li J, Wang S, Zhang Y, Qiu F, Wang T. Scutellaria baicalensis regulates FFA metabolism to ameliorate NAFLD through the AMPK- mediated SREBP signaling pathway. J Nat Med. 2018 Jun;72(3):655-666. doi: 10.1007/s11418-018-1199-5. Epub 2018 Mar 14. PMID: 29542003. 7: Guan HZ, Ding Y, Li DX, Dong H, Song JQ, Jin Y, Zhu ZJ, Sun LY, Yang YL. [Clinical diagnosis and treatment of three cases with hyperornithinemia- hyperammonemia-homocitrullinuria syndrome]. Zhonghua Er Ke Za Zhi. 2017 Jun 2;55(6):428-433. Chinese. doi: 10.3760/cma.j.issn.0578-1310.2017.06.007. PMID: 28592010. 8: Sundekilde UK, Gustavsson F, Poulsen NA, Glantz M, Paulsson M, Larsen LB, Bertram HC. Association between the bovine milk metabolome and rennet-induced coagulation properties of milk. J Dairy Sci. 2014 Oct;97(10):6076-84. doi: 10.3168/jds.2014-8304. Epub 2014 Jul 30. PMID: 25087032. 9: Held PK, Haynes CA, De Jesús VR, Baker MW. Development of an assay to simultaneously measure orotic acid, amino acids, and acylcarnitines in dried blood spots. Clin Chim Acta. 2014 Sep 25;436:149-54. doi: 10.1016/j.cca.2014.05.016. Epub 2014 Jun 2. PMID: 24886687; PMCID: PMC4835024. 10: Lu J, Boeren S, van Hooijdonk T, Vervoort J, Hettinga K. Effect of the DGAT1 K232A genotype of dairy cows on the milk metabolome and proteome. J Dairy Sci. 2015 May;98(5):3460-9. doi: 10.3168/jds.2014-8872. Epub 2015 Mar 12. PMID: 25771043.