Carnostatine HCl | CN1 Inhibitor

MedKoo Cat#: 564673 | Name: Carnostatine HCl

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Carnostatine HCl is a potent and selective carnosinase (CN1) inhibitor.

Chemical Structure

Carnostatine HCl

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564673

Name: Carnostatine HCl

CAS#: NONE

Chemical Formula: C10H17ClN4O4

Exact Mass: 0.0000

Molecular Weight: 292.72

Elemental Analysis: C, 41.03; H, 5.85; Cl, 12.11; N, 19.14; O, 21.86

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 750.00	2 Weeks
25mg	USD 1,250.00	2 Weeks

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Related CAS #

No Data

Synonym

SAN-9812; SAN 9812; SAN9812 HCl; Carnostatine HCl; Carnostatine hydrochloride;

IUPAC/Chemical Name

((S)-4-amino-2-hydroxybutanoyl)-L-histidine hydrochloride

InChi Key

DVOGVAYBGHFTIP-WSZWBAFRSA-N

InChi Code

InChI=1S/C10H16N4O4.ClH/c11-2-1-8(15)9(16)14-7(10(17)18)3-6-4-12-5-13-6;/h4-5,7-8,15H,1-3,11H2,(H,12,13)(H,14,16)(H,17,18);1H/t7-,8-;/m0./s1

SMILES Code

OC([C@@H](NC([C@@H](O)CCN)=O)CC1=CNC=N1)=O.Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

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Product Data

Product Data

Instruction

View handling instruction

Biological target:

Carnostatine hydrochloride (SAN9812 hydrochloride) is a potent and selective carnosinase 1 (CN1) inhibitor with a Ki of 11 nM for human recombinant CN1.

In vitro activity:

Carnostatine (SAN9812) also inhibits CN1 activity in human serum and serum of transgenic mice-overexpressing human CN1. Carnostatine, with an IC50 value of 18 nM on human recombinant CN1 at a carnosine concentration of 200 µM, i.e., close to the Km of 190 µM. Reference: Amino Acids. 2019 Jan;51(1):7-16. https://dx.doi.org/10.1007/s00726-018-2601-z

In vivo activity:

Subcutaneous administration of 30 mg/kg Carnostatine (SAN9812) leads to a sustained reduction in circulating CN1 activity in human CN1 transgenic (TG) mice. Simultaneous administration of Carnosine and Carnostatine increases carnosine levels in plasma and kidney by up to 100-fold compared to treatment-naïve CN1-overexpressing mice. Reference: Amino Acids. 2019 Jan;51(1):7-16. https://dx.doi.org/10.1007/s00726-018-2601-z

	Solvent	mg/mL	mM
Solubility
	Water	250.0	854.06

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 292.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

In vitro protocol:

1. Qiu J, Hauske SJ, Zhang S, Rodriguez-Niño A, Albrecht T, Pastene DO, van den Born J, van Goor H, Ruf S, Kohlmann M, Teufel M, Krämer BK, Hammes HP, Peters V, Yard BA, Kannt A. Identification and characterisation of carnostatine (SAN9812), a potent and selective carnosinase (CN1) inhibitor with in vivo activity. Amino Acids. 2019 Jan;51(1):7-16. doi: 10.1007/s00726-018-2601-z. Epub 2018 Jun 20. PMID: 29922921.

In vivo protocol:

1: Qiu J, Hauske SJ, Zhang S, Rodriguez-Niño A, Albrecht T, Pastene DO, van den Born J, van Goor H, Ruf S, Kohlmann M, Teufel M, Krämer BK, Hammes HP, Peters V, Yard BA, Kannt A. Identification and characterisation of carnostatine (SAN9812), a potent and selective carnosinase (CN1) inhibitor with in vivo activity. Amino Acids. 2018 Jun 20. doi: 10.1007/s00726-018-2601-z. [Epub ahead of print] PubMed PMID: 29922921.