Carpaine | CAS# 3463-92-1 | Antiplasmodial/Antithrombocytopenic alkaloid

MedKoo Cat#: 412386 | Name: Carpaine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Carpaine is an alkaloid originally isolated from Carica papaya that has antiplasmodial and antithrombocytopenic activities. It is active against T. b. rhodesiense, T. cruzi, and P. falciparum. Carpaine (2 mg/kg) inhibits decreases in platelet counts in a rat model of thrombocytopenia induced by busulfan. It decreases systolic, diastolic, and mean arterial blood pressure in anesthetized rats in a dose-dependent manner.

Chemical Structure

Carpaine

CAS#3463-92-1

Theoretical Analysis

MedKoo Cat#: 412386

Name: Carpaine

CAS#: 3463-92-1

Chemical Formula: C28H50N2O4

Exact Mass: 478.3771

Molecular Weight: 478.72

Elemental Analysis: C, 70.25; H, 10.53; N, 5.85; O, 13.37

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Synonym

Carpaine; EINECS 222-414-2; (+)-Carpaine; (+) Carpaine;

IUPAC/Chemical Name

(1S,11R,13S,14S,24R,26S)-13,26-dimethyl-2,15-dioxa-12,25-diazatricyclo[22.2.2.211,14]triacontane-3,16-dione

InChi Key

AMSCMASJCYVAIF-QCVMBYIASA-N

InChi Code

InChI=1S/C28H50N2O4/c1-21-25-19-17-23(29-21)13-9-5-3-8-12-16-28(32)34-26-20-18-24(30-22(26)2)14-10-6-4-7-11-15-27(31)33-25/h21-26,29-30H,3-20H2,1-2H3/t21-,22-,23+,24+,25-,26-/m0/s1

SMILES Code

C[C@@H]1N[C@@H]2CCCCCCCC(O[C@H]3CC[C@H](N[C@H]3C)CCCCCCCC(O[C@H]1CC2)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 478.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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