Carcainium (free base) | CAS# 15272-69-2 (free base) | anesthetic and potent anti-tussive activity

MedKoo Cat#: 412331 | Name: Carcainium (free base)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Carcainium (free base) is phenylcarbamoylmethyl derivative with local anesthetic and potent anti-tussive activity. In preclinical studies Carcainium significantly reduced the spontaneous and histamine-evoked discharges in Aδ-fibres originating from airway, rapidly adapting stretch receptors (RARs) without affecting histamine-evoked bronchoconstriction. Acute pre-treatment of guinea-pigs with aerosols of Carcainium prevent of capsaicin-evoked and citric acid-induced coughs.

Chemical Structure

Carcainium (free base)

CAS#15272-69-2 (free base)

Theoretical Analysis

MedKoo Cat#: 412331

Name: Carcainium (free base)

CAS#: 15272-69-2 (free base)

Chemical Formula: C18H22N3O2+

Exact Mass: 312.1707

Molecular Weight: 312.39

Elemental Analysis: C, 69.21; H, 7.10; N, 13.45; O, 10.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1042-42-8 (Cl) 15272-69-2 (free base)

Synonym

Carcainium (free base); UNII-4T82CRD6TM

IUPAC/Chemical Name

Dimethylbis((phenylcarbamoyl)methyl)ammonium

InChi Key

MPOXTHSNJVUPKR-UHFFFAOYSA-O

InChi Code

InChI=1S/C18H21N3O2/c1-21(2,13-17(22)19-15-9-5-3-6-10-15)14-18(23)20-16-11-7-4-8-12-16/h3-12H,13-14H2,1-2H3,(H-,19,20,22,23)/p+1

SMILES Code

O=C(C[N+](C)(C)CC(NC1=CC=CC=C1)=O)NC2=CC=CC=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 312.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lavorini F, Spina D, Walker MJ, Franciosi L, Page CP, Fontana GA. Antitussive effect of carcainium chloride in patients with chronic cough and idiopathic interstitial pneumonias: A pilot study. Pulm Pharmacol Ther. 2016 Oct;40:91-4. doi: 10.1016/j.pupt.2016.08.001. Epub 2016 Aug 15. PMID: 27538683. 2: Adcock JJ, Douglas GJ, Garabette M, Gascoigne M, Beatch G, Walker M, Page CP. RSD931, a novel anti-tussive agent acting on airway sensory nerves. Br J Pharmacol. 2003 Feb;138(3):407-16. doi: 10.1038/sj.bjp.0705056. PMID: 12569065; PMCID: PMC1573683. 3: Shao CJ, Gao Y, Zhao L, Jin D, Wang D, Wang DQ. Co-application of lidocaine and QX-572 induces divergent pain behaviours in mice. J Pharm Pharmacol. 2015 Sep;67(9):1272-8. doi: 10.1111/jphp.12419. Epub 2015 Apr 23. PMID: 25904024. 4: Schönfeld P, Sztark F, Slimani M, Dabadie P, Mazat JP. Is bupivacaine a decoupler, a protonophore or a proton-leak-inducer? FEBS Lett. 1992 Jun 15;304(2-3):273-6. doi: 10.1016/0014-5793(92)80636-u. PMID: 1618334. 5: KATZ RL. ANTIARRHYTHMIC AND NEUROMUSCULAR EFFECTS OF QX-572 IN MAN. Acta Anaesthesiol Scand. 1965;9:73-81. doi: 10.1111/j.1399-6576.1965.tb00496.x. PMID: 14319089. 6: Lyttkens L, Larsson B, Wästerström SA. Local anaesthetics and tinnitus. Proposed peripheral mechanism of action of lidocaine. ORL J Otorhinolaryngol Relat Spec. 1984;46(1):17-23. doi: 10.1159/000275679. PMID: 6700953. 7: COVINO BG, RACHWALL P. COMPARATIVE CARDIAC EFFECTS OF QUINIDINE AND N,N-BIS(PHENYLCARBAMOYLMETHYL)-DIMETHYLAMMONIUM CHLORIDE (QX-572), A NEW ANTIARRHYTHMIC AGENT. J New Drugs. 1964 Jan-Feb;4(1):30-7. doi: 10.1002/j.1552-4604.1964.tb00100.x. PMID: 14157082. 8: KATZ RL. ANTIARRHYTHMIC ACTION OF N, N-BIS (PHENYLCARBAMOYLMETHYL) DIMETHYL AMMONIUM CHLORIDE (QX-572) IN CAT AND DOG. Anesthesiology. 1964 May- Jun;25:291-6. doi: 10.1097/00000542-196405000-00005. PMID: 14156568. 9: Huang LM, Ehrenstein G. Local anesthetics QX 572 and benzocaine act at separate sites on the batrachotoxin-activated sodium channel. J Gen Physiol. 1981 Feb;77(2):137-53. doi: 10.1085/jgp.77.2.137. PMID: 6267160; PMCID: PMC2215428. 10: Gendenshteĭn EI, Tsybusov AP. Nekotorye mestnye anestetiki i ikh chetvertichnye proizvodnye kak protivoaritmicheskie sredstva [Local anesthetics and their quaternary derivatives as anti-arrhythmia agents]. Farmakol Toksikol. 1985 Jan-Feb;48(1):112-7. Russian. PMID: 2579846.