Synonym
Carcainium chloride; QX572; QX-572; QX 572
IUPAC/Chemical Name
Ammonium, dimethylbis((phenylcarbamoyl)methyl)-, chloride (8CI)
InChi Key
YGCONRRHHMKQRL-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H21N3O2.ClH/c1-21(2,13-17(22)19-15-9-5-3-6-10-15)14-18(23)20-16-11-7-4-8-12-16;/h3-12H,13-14H2,1-2H3,(H-,19,20,22,23);1H
SMILES Code
O=C(C[N+](C)(C)CC(NC1=CC=CC=C1)=O)NC2=CC=CC=C2.[Cl-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
347.84
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lavorini F, Spina D, Walker MJ, Franciosi L, Page CP, Fontana GA. Antitussive effect of carcainium chloride in patients with chronic cough and idiopathic interstitial pneumonias: A pilot study. Pulm Pharmacol Ther. 2016 Oct;40:91-4. doi: 10.1016/j.pupt.2016.08.001. Epub 2016 Aug 15. PMID: 27538683.
2: Adcock JJ, Douglas GJ, Garabette M, Gascoigne M, Beatch G, Walker M, Page CP. RSD931, a novel anti-tussive agent acting on airway sensory nerves. Br J Pharmacol. 2003 Feb;138(3):407-16. doi: 10.1038/sj.bjp.0705056. PMID: 12569065; PMCID: PMC1573683.
3: COVINO BG, RACHWALL P. COMPARATIVE CARDIAC EFFECTS OF QUINIDINE AND N,N-BIS(PHENYLCARBAMOYLMETHYL)-DIMETHYLAMMONIUM CHLORIDE (QX-572), A NEW ANTIARRHYTHMIC AGENT. J New Drugs. 1964 Jan-Feb;4(1):30-7. doi: 10.1002/j.1552-4604.1964.tb00100.x. PMID: 14157082.
4: KATZ RL. ANTIARRHYTHMIC ACTION OF N, N-BIS (PHENYLCARBAMOYLMETHYL) DIMETHYL AMMONIUM CHLORIDE (QX-572) IN CAT AND DOG. Anesthesiology. 1964 May- Jun;25:291-6. doi: 10.1097/00000542-196405000-00005. PMID: 14156568.
5: Shao CJ, Gao Y, Zhao L, Jin D, Wang D, Wang DQ. Co-application of lidocaine and QX-572 induces divergent pain behaviours in mice. J Pharm Pharmacol. 2015 Sep;67(9):1272-8. doi: 10.1111/jphp.12419. Epub 2015 Apr 23. PMID: 25904024.
6: Schönfeld P, Sztark F, Slimani M, Dabadie P, Mazat JP. Is bupivacaine a decoupler, a protonophore or a proton-leak-inducer? FEBS Lett. 1992 Jun 15;304(2-3):273-6. doi: 10.1016/0014-5793(92)80636-u. PMID: 1618334.
7: KATZ RL. ANTIARRHYTHMIC AND NEUROMUSCULAR EFFECTS OF QX-572 IN MAN. Acta Anaesthesiol Scand. 1965;9:73-81. doi: 10.1111/j.1399-6576.1965.tb00496.x. PMID: 14319089.
8: Lyttkens L, Larsson B, Wästerström SA. Local anaesthetics and tinnitus. Proposed peripheral mechanism of action of lidocaine. ORL J Otorhinolaryngol Relat Spec. 1984;46(1):17-23. doi: 10.1159/000275679. PMID: 6700953.
9: Huang LM, Ehrenstein G. Local anesthetics QX 572 and benzocaine act at separate sites on the batrachotoxin-activated sodium channel. J Gen Physiol. 1981 Feb;77(2):137-53. doi: 10.1085/jgp.77.2.137. PMID: 6267160; PMCID: PMC2215428.
10: Gendenshteĭn EI, Tsybusov AP. Nekotorye mestnye anestetiki i ikh chetvertichnye proizvodnye kak protivoaritmicheskie sredstva [Local anesthetics and their quaternary derivatives as anti-arrhythmia agents]. Farmakol Toksikol. 1985 Jan-Feb;48(1):112-7. Russian. PMID: 2579846.
