Apraclonidine | CAS# 66711-21-5 | α2-adrenergic agonist

MedKoo Cat#: 574970 | Name: Apraclonidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Apraclonidine, also known as Iopidine, is a sympathomimetic used in glaucoma therapy. It is an α2-adrenergic agonist and a weak alpha-1 adrenergic receptor agonist. Upon ocular administration, apraclonidine enhances aqueous humor uveoscleral outflow and decreases aqueous production by vasoconstriction.

Chemical Structure

Apraclonidine

CAS#66711-21-5 (free base)

Theoretical Analysis

MedKoo Cat#: 574970

Name: Apraclonidine

CAS#: 66711-21-5 (free base)

Chemical Formula: C9H10Cl2N4

Exact Mass: 244.0283

Molecular Weight: 245.11

Elemental Analysis: C, 44.10; H, 4.11; Cl, 28.93; N, 22.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

73218-79-8 (HCl) 66711-21-5 (free base)

Synonym

Apraclonidine; Iopidine

IUPAC/Chemical Name

2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine

InChi Key

IEJXVRYNEISIKR-UHFFFAOYSA-N

InChi Code

InChI=1S/C9H10Cl2N4/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9/h3-4H,1-2,12H2,(H2,13,14,15)

SMILES Code

NC1=CC(Cl)=C(C(Cl)=C1)NC2=NCCN2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 245.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kauh CY, Bursztyn LL. Positive Apraclonidine Test in Horner Syndrome Caused by Thalamic Hemorrhage. J Neuroophthalmol. 2015 Sep;35(3):287-8. doi: 10.1097/WNO.0000000000000222. PubMed PMID: 25768246. 2: Eguchi R, Takagi C, Ishikawa N, Ando H, Ando N. [Factors influencing intraocular pressure elevation on the first postoperative day following small-incision cataract surgery--the effect of apraclonidine]. Nippon Ganka Gakkai Zasshi. 2014 Sep;118(9):768-72. Japanese. PubMed PMID: 25318185. 3: Shin RK, Cheek AG. Teaching NeuroImages: Positive apraclonidine test in Horner syndrome. Neurology. 2011 May 17;76(20):e100. doi: 10.1212/WNL.0b013e31821a4454. PubMed PMID: 21576682. 4: Cooper-Knock J, Pepper I, Hodgson T, Sharrack B. Early diagnosis of Horner syndrome using topical apraclonidine. J Neuroophthalmol. 2011 Sep;31(3):214-6. doi: 10.1097/WNO.0b013e31821a91fe. PubMed PMID: 21566530.

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MedKoo CAT#: 565294

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